Role of Lectin-Like Oxidized Low Density Lipoprotein-1 in Fetoplacental Vascular Dysfunction in Preeclampsia
Joint Authors
Escudero, Carlos
Gutierrez, Nicolas
Aguilera, Valeria
Aguayo, Claudio
Ormazabal, Valeska
Zuniga, Felipe A.
Lamperti, Liliana
Veas, Carlos
Radojkovic, Claudia
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-06
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The bioavailability of nitric oxide (NO) represents a key marker in vascular health.
A decrease in NO induces a pathological condition denominated endothelial dysfunction, syndrome observed in different pathologies, such as obesity, diabetes, kidney disease, cardiovascular disease, and preeclampsia (PE).
PE is one of the major risks for maternal death and fetal loss.
Recent studies suggest that the placenta of pregnant women with PE express high levels of lectin-like oxidized LDL receptor-1 (LOX-1), which induces endothelial dysfunction by increasing reactive oxygen species (ROS) and decreasing intracellular NO.
Besides LOX-1 activation induces changes in migration and apoptosis of syncytiotrophoblast cells.
However, the role of this receptor in placental tissue is still unknown.
In this review we will describes the physiological roles of LOX-1 in normal placenta development and the potential involvement of this receptor in the pathophysiology of PE.
American Psychological Association (APA)
Zuniga, Felipe A.& Ormazabal, Valeska& Gutierrez, Nicolas& Aguilera, Valeria& Radojkovic, Claudia& Veas, Carlos…[et al.]. 2014. Role of Lectin-Like Oxidized Low Density Lipoprotein-1 in Fetoplacental Vascular Dysfunction in Preeclampsia. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-465233
Modern Language Association (MLA)
Zuniga, Felipe A.…[et al.]. Role of Lectin-Like Oxidized Low Density Lipoprotein-1 in Fetoplacental Vascular Dysfunction in Preeclampsia. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-465233
American Medical Association (AMA)
Zuniga, Felipe A.& Ormazabal, Valeska& Gutierrez, Nicolas& Aguilera, Valeria& Radojkovic, Claudia& Veas, Carlos…[et al.]. Role of Lectin-Like Oxidized Low Density Lipoprotein-1 in Fetoplacental Vascular Dysfunction in Preeclampsia. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-465233
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465233