The Effect of Multidisciplinary Lifestyle Intervention on the Pre- and Postprandial Plasma Gut Peptide Concentrations in Children with Obesity

Abstract EN

Objective.

This study aims to evaluate the effect of a multidisciplinary treatment of obesity on plasma concentrations of several gut hormones in fasting condition and in response to a mixed meal in children.

Methods.

Complete data were available from 36 obese children (age 13.3±2.0 yr).

At baseline and after the 3-month multidisciplinary treatment, fasting and postprandial blood samples were taken for glucose, insulin, ghrelin, peptide YY (PYY), and glucagon-like peptide 1 (GLP-1).

Results.

BMI-SDS was significantly reduced by multidisciplinary treatment (from 4.2±0.7 to 4.0±0.9, P<.01).

The intervention significantly increased the area under the curve (AUC) of ghrelin (from 92.3±18.3 to 97.9±18.2 pg/L, P<.01), but no significant changes were found for PYY or GLP-1 concentrations (in fasting or postprandial condition).

The insulin resistance index (HOMA-IR) remained unchanged as well.

Conclusion.

Intensive multidisciplinary treatment induced moderate weight loss and increased ghrelin secretion, but serum PYY and GLP-1 concentrations and insulin sensitivity remained unchanged.