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Integrin Signaling in Oligodendrocytes and Its Importance in CNS Myelination
Joint Authors
Michalski, John-Paul
O'Meara, Ryan W.
Kothary, Rashmi
Source
Journal of Signal Transduction
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-20
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Multiple sclerosis is characterized by repeated demyelinating attacks of the central nervous system (CNS) white matter tracts.
To tailor novel therapeutics to halt or reverse disease process, we require a better understanding of oligodendrocyte biology and of the molecular mechanisms that initiate myelination.
Cell extrinsic mechanisms regulate CNS myelination through the interaction of extracellular matrix proteins and their transmembrane receptors.
The engagement of one such receptor family, the integrins, initiates intracellular signaling cascades that lead to changes in cell phenotype.
Oligodendrocytes express a diverse array of integrins, and the expression of these receptors is developmentally regulated.
Integrin-mediated signaling is crucial to the proliferation, survival, and maturation of oligodendrocytes through the activation of downstream signaling pathways involved in cytoskeletal remodeling.
Here, we review the current understanding of this important signaling axis and its role in oligodendrocyte biology and ultimately in the myelination of axons within the CNS.
American Psychological Association (APA)
O'Meara, Ryan W.& Michalski, John-Paul& Kothary, Rashmi. 2010. Integrin Signaling in Oligodendrocytes and Its Importance in CNS Myelination. Journal of Signal Transduction،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-465276
Modern Language Association (MLA)
O'Meara, Ryan W.…[et al.]. Integrin Signaling in Oligodendrocytes and Its Importance in CNS Myelination. Journal of Signal Transduction No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-465276
American Medical Association (AMA)
O'Meara, Ryan W.& Michalski, John-Paul& Kothary, Rashmi. Integrin Signaling in Oligodendrocytes and Its Importance in CNS Myelination. Journal of Signal Transduction. 2010. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-465276
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465276