Characterization of Musclin as a New Target for Treatment of Hypertension
Joint Authors
Tsai, Cheng-Chia
Chang, Chen Kuei
Niu, Chiang-Shan
Chen, Li-Jen
Niu, Ho-Shan
Lin, Jia-Wei
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Musclin is a novel skeletal muscle-derived factor found in the signal sequence trap of mouse skeletal muscle cDNAs.
Recently, it has been demonstrated that musclin is involved in the pathogenesis of spontaneously hypertensive rats (SHRs).
However, it is known as a genetic hypertension model.
In the present study, we aim to investigate the role of musclin in another animal model of hypertension and characterize the direct effect of musclin on vascular contraction.
The results show that expression of musclin was increased in arterial tissues isolated from DOCA-salt induced hypertensive rats or the normal rats received repeated vasoconstriction with phenylephrine.
Additionally, direct incubation with phenylephrine did not modify the expression of musclin in the in vitro studies.
Also, the direct effect of musclin on the increase of intracellular calcium was observed in a concentration-dependent manner.
These results provide the evidence to support that musclin is involved in hypertension.
Thus, musclin is suitable to be considered as a novel target for treatment of hypertension.
American Psychological Association (APA)
Lin, Jia-Wei& Tsai, Cheng-Chia& Chen, Li-Jen& Niu, Ho-Shan& Chang, Chen Kuei& Niu, Chiang-Shan. 2014. Characterization of Musclin as a New Target for Treatment of Hypertension. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-465300
Modern Language Association (MLA)
Lin, Jia-Wei…[et al.]. Characterization of Musclin as a New Target for Treatment of Hypertension. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-465300
American Medical Association (AMA)
Lin, Jia-Wei& Tsai, Cheng-Chia& Chen, Li-Jen& Niu, Ho-Shan& Chang, Chen Kuei& Niu, Chiang-Shan. Characterization of Musclin as a New Target for Treatment of Hypertension. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-465300
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465300