Convenient and Scalable Synthesis of Fmoc-Protected Peptide Nucleic Acid Backbone
Joint Authors
Heemstra, Jennifer M.
Shah, Nirmal I.
Feagin, Trevor A.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-10
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The peptide nucleic acid backbone Fmoc-AEG-OBn has been synthesized via a scalable and cost-effective route.
Ethylenediamine is mono-Boc protected, then alkylated with benzyl bromoacetate.
The Boc group is removed and replaced with an Fmoc group.
The synthesis was performed starting with 50 g of Boc anhydride to give 31 g of product in 32% overall yield.
The Fmoc-protected PNA backbone is a key intermediate in the synthesis of nucleobase-modified PNA monomers.
Thus, improved access to this molecule is anticipated to facilitate future investigations into the chemical properties and applications of nucleobase-modified PNA.
American Psychological Association (APA)
Feagin, Trevor A.& Shah, Nirmal I.& Heemstra, Jennifer M.. 2012. Convenient and Scalable Synthesis of Fmoc-Protected Peptide Nucleic Acid Backbone. Journal of Nucleic Acids،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-465311
Modern Language Association (MLA)
Feagin, Trevor A.…[et al.]. Convenient and Scalable Synthesis of Fmoc-Protected Peptide Nucleic Acid Backbone. Journal of Nucleic Acids No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-465311
American Medical Association (AMA)
Feagin, Trevor A.& Shah, Nirmal I.& Heemstra, Jennifer M.. Convenient and Scalable Synthesis of Fmoc-Protected Peptide Nucleic Acid Backbone. Journal of Nucleic Acids. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-465311
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465311
