Endothelin-1 Role in Human Eye : A Review
Joint Authors
Salvatore, Serena
Vingolo, Enzo Maria
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-03
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Endothelin is a potent vasoactive peptide occurring in three isotypes, ET-1, ET-2, and ET-3.
Through its two main receptors, endothelin A and endothelin B, it is responsible for a variety of physiological functions, primarily blood flow control.
Recent evidence from both human and animal models shows involvement of endothelin in diabetes, retinal circulation, and optic neuropathies.
Increased circulating levels of endothelin-1 (ET-1) have been found in patients with diabetes, and a positive correlation between plasma ET-1 levels and microangiopathy in patients with type-2 diabetes has been demonstrated.
In addition to its direct vasoconstrictor effects, enhanced levels of ET-1 may contribute to endothelial dysfunction through inhibitory effects on nitric oxide (NO) production.
Experimental studies have shown that chronic ET-1 administration to the optic nerve immediately behind the globe causes neuronal damage, activation of astrocytes, the major glial cell in the anterior optic nerve, and upregulation of endothelin B receptors.
This paper outlines the ubiquitous role of endothelin and its potential involvement in ophthalmology.
American Psychological Association (APA)
Salvatore, Serena& Vingolo, Enzo Maria. 2011. Endothelin-1 Role in Human Eye : A Review. Journal of Ophthalmology،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-465320
Modern Language Association (MLA)
Salvatore, Serena& Vingolo, Enzo Maria. Endothelin-1 Role in Human Eye : A Review. Journal of Ophthalmology No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-465320
American Medical Association (AMA)
Salvatore, Serena& Vingolo, Enzo Maria. Endothelin-1 Role in Human Eye : A Review. Journal of Ophthalmology. 2011. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-465320
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465320