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Treatment of Non-Small-Cell Lung Cancer with Erlotinib following Gefitinib-Induced Hepatotoxicity : Review of 8 Clinical Cases
Joint Authors
Yokota, Soichiro
Mori, Masahide
Kagami, Shinichi
Namba, Yoshinobu
Nakazawa, Yukie
Yano, Yukihiro
Kimura, Hiromi
Yoneda, Tsutomu
Niinaka, Manabu
Yamaguchi, Toshihiko
Nashi, Ayumi
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-08
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
Gefitinib often induces liver damage.
A few reports have described that the subsequent administration of erlotinib was associated with less hepatotoxicity, but the safety and efficacy of this treatment are still not fully investigated.
Therefore, we evaluated retrospectively the patients with erlotinib following gefitinib-induced hepatotoxicity.
Methods and Patients.
We retrospectively reviewed the medical records between December 2007 and March 2010.
The patients were evaluated including the following information: age, gender, histology of lung cancer, performance status, smoking status, epidermal growth factor receptor (EGFR) mutation status, liver metastasis, viral hepatitis, alcoholic liver injury, clinical response, and hepatotoxicity due to EGFR tyrosine kinase inhibitors.
Results.
We identified 8 patients with erlotinib following gefitinib-induced hepatotoxicity.
All achieved disease control by gefitinib.
Hepatotoxicity was grades 2 and 3 in 3 and 5 patients, respectively.
The median duration of treatment with gefitinib was 112.5 days and the median time to gefitinib-induced hepatotoxicity was 51.5 days.
The median duration of treatment with erlotinib was 171.5 days.
Grade 1 and 2 erlotinib-induced hepatotoxicity was observed in 2 and 1 patient, respectively.
Conclusions.
Erlotinib administration with careful monitoring is thought to be a good alternative strategy for patients who respond well to gefitinib treatment but experience hepatotoxicity.
American Psychological Association (APA)
Yano, Yukihiro& Namba, Yoshinobu& Mori, Masahide& Nakazawa, Yukie& Nashi, Ayumi& Kagami, Shinichi…[et al.]. 2012. Treatment of Non-Small-Cell Lung Cancer with Erlotinib following Gefitinib-Induced Hepatotoxicity : Review of 8 Clinical Cases. Lung Cancer International،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-465324
Modern Language Association (MLA)
Yano, Yukihiro…[et al.]. Treatment of Non-Small-Cell Lung Cancer with Erlotinib following Gefitinib-Induced Hepatotoxicity : Review of 8 Clinical Cases. Lung Cancer International No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-465324
American Medical Association (AMA)
Yano, Yukihiro& Namba, Yoshinobu& Mori, Masahide& Nakazawa, Yukie& Nashi, Ayumi& Kagami, Shinichi…[et al.]. Treatment of Non-Small-Cell Lung Cancer with Erlotinib following Gefitinib-Induced Hepatotoxicity : Review of 8 Clinical Cases. Lung Cancer International. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-465324
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465324