Evodiamine Induces Transient Receptor Potential Vanilloid-1-Mediated Protective Autophagy in U87-MG Astrocytes
Joint Authors
Hou, Sz-Ying
Lin, Chien-Ju
Wang, Sheng-Hao
Shih, Chwen-Ming
Chen, Thay-Hsiung
Liu, Ann-Jeng
Hsiao, Sheng-Huang
Chiu, Wen-Ta
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Cerebral ischemia is a leading cause of mortality and morbidity worldwide, which results in cognitive and motor dysfunction, neurodegenerative diseases, and death.
Evodiamine (Evo) is extracted from Evodia rutaecarpa Bentham, a plant widely used in Chinese herbal medicine, which possesses variable biological abilities, such as anticancer, anti-inflammation, antiobesity, anti-Alzheimer’s disease, antimetastatic, antianoxic, and antinociceptive functions.
But the effect of Evo on ischemic stroke is unclear.
Increasing data suggest that activation of autophagy, an adaptive response to environmental stresses, could protect neurons from ischemia-induced cell death.
In this study, we found that Evo induced autophagy in U87-MG astrocytes.
A scavenger of extracellular calcium and an antagonist of transient receptor potential vanilloid-1 (TRPV-1) decreased the percentage of autophagy accompanied by an increase in apoptosis, suggesting that Evo may induce calcium-mediated protective autophagy resulting from an influx of extracellular calcium.
The same phenomena were also confirmed by a small interfering RNA technique to knock down the expression of TRPV1.
Finally, Evo-induced c-Jun N-terminal kinases (JNK) activation was reduced by a TRPV1 antagonist, indicating that Evo-induced autophagy may occur through a calcium/c-Jun N-terminal kinase (JNK) pathway.
Collectively, Evo induced an influx of extracellular calcium, which led to JNK-mediated protective autophagy, and this provides a new option for ischemic stroke treatment.
American Psychological Association (APA)
Liu, Ann-Jeng& Wang, Sheng-Hao& Hou, Sz-Ying& Lin, Chien-Ju& Chiu, Wen-Ta& Hsiao, Sheng-Huang…[et al.]. 2013. Evodiamine Induces Transient Receptor Potential Vanilloid-1-Mediated Protective Autophagy in U87-MG Astrocytes. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-465347
Modern Language Association (MLA)
Liu, Ann-Jeng…[et al.]. Evodiamine Induces Transient Receptor Potential Vanilloid-1-Mediated Protective Autophagy in U87-MG Astrocytes. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-465347
American Medical Association (AMA)
Liu, Ann-Jeng& Wang, Sheng-Hao& Hou, Sz-Ying& Lin, Chien-Ju& Chiu, Wen-Ta& Hsiao, Sheng-Huang…[et al.]. Evodiamine Induces Transient Receptor Potential Vanilloid-1-Mediated Protective Autophagy in U87-MG Astrocytes. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-465347
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465347