![](/images/graphics-bg.png)
Whole Slide Quantification of Stromal Lymphatic Vessel Distribution and Peritumoral Lymphatic Vessel Density in Early Invasive Cervical Cancer : A Method Description
Joint Authors
Foidart, Jean-Michel
Beliard, A.
Signolle, N.
Blacher, S.
Kridelka, Frederic
Balsat, C.
Munaut, C.
Goffin, Frederic
Noel, Agnes
Source
ISRN Obstetrics and Gynecology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-25
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Peritumoral Lymphatic Vessel Density (LVD) is considered to be a predictive marker for the presence of lymph node metastases in cervical cancer.
However, when LVD quantification relies on conventional optical microscopy and the hot spot technique, interobserver variability is significant and yields inconsistent conclusions.
In this work, we describe an original method that applies computed image analysis to whole slide scanned tissue sections following immunohistochemical lymphatic vessel staining.
This procedure allows to determine an objective LVD quantification as well as the lymphatic vessel distribution and its heterogeneity within the stroma surrounding the invasive tumor bundles.
The proposed technique can be useful to better characterize lymphatic vessel interactions with tumor cells and could potentially impact on prognosis and therapeutic decisions.
American Psychological Association (APA)
Balsat, C.& Blacher, S.& Signolle, N.& Beliard, A.& Munaut, C.& Goffin, Frederic…[et al.]. 2011. Whole Slide Quantification of Stromal Lymphatic Vessel Distribution and Peritumoral Lymphatic Vessel Density in Early Invasive Cervical Cancer : A Method Description. ISRN Obstetrics and Gynecology،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-465348
Modern Language Association (MLA)
Balsat, C.…[et al.]. Whole Slide Quantification of Stromal Lymphatic Vessel Distribution and Peritumoral Lymphatic Vessel Density in Early Invasive Cervical Cancer : A Method Description. ISRN Obstetrics and Gynecology No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-465348
American Medical Association (AMA)
Balsat, C.& Blacher, S.& Signolle, N.& Beliard, A.& Munaut, C.& Goffin, Frederic…[et al.]. Whole Slide Quantification of Stromal Lymphatic Vessel Distribution and Peritumoral Lymphatic Vessel Density in Early Invasive Cervical Cancer : A Method Description. ISRN Obstetrics and Gynecology. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-465348
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465348