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Tenofovir Nephrotoxicity : 2011 Update
Joint Authors
Arduán, Alberto Ortiz
Izquierdo, Maria C.
Sanchez-Niño, Maria D.
Sainz-Prestel, Valeria
Selgas, Rafael
Ruiz-Ortega, Marta
Egido, Jesus
Montoya-Ferrer, Ana
Fernandez-Fernandez, Beatriz
Ortiz-Martin, Natalia
Poveda, Jonay
Parra-Rodriguez, Alejandro
Sanz, Ana B.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-07
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Tenofovir is an acyclic nucleotide analogue reverse-transcriptase inhibitor structurally similar to the nephrotoxic drugs adefovir and cidofovir.
Tenofovir is widely used to treat HIV infection and approved for treatment of hepatitis B virus.
Despite initial cell culture and clinical trials results supporting the renal safety of tenofovir, its clinical use is associated with a low, albeit significant, risk of kidney injury.
Proximal tubular cell secretion of tenofovir explains the accumulation of the drug in these mitochondria-rich cells.
Tenofovir nephrotoxicity is characterized by proximal tubular cell dysfunction that may be associated with acute kidney injury or chronic kidney disease.
Withdrawal of the drug leads to improvement of analytical parameters that may be partial.
Understanding the risk factors for nephrotoxicity and regular monitoring of proximal tubular dysfunction and serum creatinine in high-risk patients is required to minimize nephrotoxicity.
Newer, structurally similar molecular derivatives that do not accumulate in proximal tubules are under study.
American Psychological Association (APA)
Fernandez-Fernandez, Beatriz& Montoya-Ferrer, Ana& Sanz, Ana B.& Sanchez-Niño, Maria D.& Izquierdo, Maria C.& Poveda, Jonay…[et al.]. 2011. Tenofovir Nephrotoxicity : 2011 Update. AIDS Research and Treatment،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-465353
Modern Language Association (MLA)
Fernandez-Fernandez, Beatriz…[et al.]. Tenofovir Nephrotoxicity : 2011 Update. AIDS Research and Treatment No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-465353
American Medical Association (AMA)
Fernandez-Fernandez, Beatriz& Montoya-Ferrer, Ana& Sanz, Ana B.& Sanchez-Niño, Maria D.& Izquierdo, Maria C.& Poveda, Jonay…[et al.]. Tenofovir Nephrotoxicity : 2011 Update. AIDS Research and Treatment. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-465353
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465353