The Physiological Role of Mitophagy : New Insights into Phosphorylation Events
Joint Authors
Kang, Dongchon
Hirota, Yuko
Kanki, Tomotake
Source
International Journal of Cell Biology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Mitochondria play an essential role in oxidative phosphorylation, fatty acid oxidation, and the regulation of apoptosis.
However, this organelle also produces reactive oxygen species (ROS) that continually inflict oxidative damage on mitochondrial DNA, proteins, and lipids, which causes further production of ROS.
To oppose this oxidative stress, mitochondria possess quality control systems that include antioxidant enzymes and the repair or degradation of damaged mitochondrial DNA and proteins.
If the oxidative stress exceeds the capacity of the mitochondrial quality control system, it seems that autophagy degrades the damaged mitochondria to maintain cellular homeostasis.
Indeed, recent evidence from yeast to mammals indicates that the autophagy-dependent degradation of mitochondria (mitophagy) contributes to eliminate dysfunctional, aged, or excess mitochondria.
In this paper, we describe the molecular processes and regulatory mechanisms of mitophagy in yeast and mammalian cells.
American Psychological Association (APA)
Hirota, Yuko& Kang, Dongchon& Kanki, Tomotake. 2012. The Physiological Role of Mitophagy : New Insights into Phosphorylation Events. International Journal of Cell Biology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-465354
Modern Language Association (MLA)
Hirota, Yuko…[et al.]. The Physiological Role of Mitophagy : New Insights into Phosphorylation Events. International Journal of Cell Biology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-465354
American Medical Association (AMA)
Hirota, Yuko& Kang, Dongchon& Kanki, Tomotake. The Physiological Role of Mitophagy : New Insights into Phosphorylation Events. International Journal of Cell Biology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-465354
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465354