Association between the Delta Estimated Glomerular Filtration Rate and the Prevalence of Monoclonal Gammopathy of Undetermined Significance in Korean Males
Joint Authors
Chun, Sail
Lee, Woochang
Min, Won-Ki
Jeong, Tae-Dong
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-08
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
We investigated the association between the reduction in the estimated glomerular filtration rate (eGFR) and the prevalence of monoclonal gammopathy of undetermined significance (MGUS) in Korean males.
Methods.
We enrolled 723 healthy Korean males.
Serum creatinine concentration, serum electrophoresis, serum immunofixation, and the serum free light chain assay were performed.
We calculated delta eGFR per year (ΔeGFR/yr).
The prevalence of MGUS was compared based on the ΔeGFR/yr and age group.
Results.
Thirteen (1.8%) of 723 participants exhibited the monoclonal band on serum immunofixation.
Prevalence of MGUS by age group was 0.00% (0/172 for 40 years), 1.63% (6/367 for 60 years), and 3.80% (7/184 for >60 years).
The median decrease in ΔeGFR/yr was 5.3%.
The prevalence of MGUS in participants in their 50s with >5.3% decline in ΔeGFR/yr was significantly higher than those with <5.3% decrease in ΔeGFR/yr (3.16% versus 0.00%; P=0.049).
The prevalence of MGUS in participants in their 50s with >5.3% decrease in ΔeGFR/yr was similar to that of healthy males in their 60s.
Conclusion.
Using the rate of reduction in ΔeGFR/yr in healthy Korean males who had their serum creatinine level checked regularly may increase the MGUS detection rate in clinical practice.
American Psychological Association (APA)
Jeong, Tae-Dong& Lee, Woochang& Chun, Sail& Min, Won-Ki. 2014. Association between the Delta Estimated Glomerular Filtration Rate and the Prevalence of Monoclonal Gammopathy of Undetermined Significance in Korean Males. BioMed Research International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-465371
Modern Language Association (MLA)
Jeong, Tae-Dong…[et al.]. Association between the Delta Estimated Glomerular Filtration Rate and the Prevalence of Monoclonal Gammopathy of Undetermined Significance in Korean Males. BioMed Research International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-465371
American Medical Association (AMA)
Jeong, Tae-Dong& Lee, Woochang& Chun, Sail& Min, Won-Ki. Association between the Delta Estimated Glomerular Filtration Rate and the Prevalence of Monoclonal Gammopathy of Undetermined Significance in Korean Males. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-465371
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465371