Genetic Variations of Glutathione S-Transferase Influence on Blood Cadmium Concentration
Joint Authors
Hengprasith, Bunlue
Sritara, Piyamit
Suwannathon, Lerson
Chanprasertyothin, Suwannee
Khansakorn, Nitchaphat
Sura, Thunyachai
Tharnpoophasiam, Prapin
Wongwit, Waranya
Kaojarern, Sming
Sirivarasai, Jintana
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-12
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Pharmacy, Health & Medical Sciences
Medicine
Abstract EN
The glutathione S-transferases (GSTs) are involved in biotransformation and detoxification of cadmium (Cd).
Genetic polymorphisms in these genes may lead to interindividual variation in Cd susceptibility.
The objective of this study was to assess the association of GSTs (GSTT1, GSTM1, and GSTP1 Val105Ile) polymorphisms with blood Cd concentrations in a nonoccupationally exposed population.
The 370 blood samples were analyzed for Cd concentration and polymorphisms in GSTs genes.
Geometric mean of blood Cd among this population was 0.46±0.02 μg/L (with 95% CI; 0.43–0.49 μg/L).
Blood Cd concentrations in subjects carrying GSTP1 Val/Val genotype were significantly higher than those with Ile/Ile and Ile/Val genotypes.
No significant differences in blood Cd concentrations among individual with gene deletions of GSTT1 and GSTM1 were observed.
GSTP1/GSTT1 and GSTP1/GSTM1 combinations showed significantly associated with increase in blood Cd levels.
This study indicated that polymorphisms of GSTP1 combined with GSTT1 and/or GSTM1 deletion are likely to influence on individual susceptibility to cadmium toxicity.
American Psychological Association (APA)
Khansakorn, Nitchaphat& Wongwit, Waranya& Tharnpoophasiam, Prapin& Hengprasith, Bunlue& Suwannathon, Lerson& Chanprasertyothin, Suwannee…[et al.]. 2012. Genetic Variations of Glutathione S-Transferase Influence on Blood Cadmium Concentration. Journal of Toxicology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-465380
Modern Language Association (MLA)
Khansakorn, Nitchaphat…[et al.]. Genetic Variations of Glutathione S-Transferase Influence on Blood Cadmium Concentration. Journal of Toxicology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-465380
American Medical Association (AMA)
Khansakorn, Nitchaphat& Wongwit, Waranya& Tharnpoophasiam, Prapin& Hengprasith, Bunlue& Suwannathon, Lerson& Chanprasertyothin, Suwannee…[et al.]. Genetic Variations of Glutathione S-Transferase Influence on Blood Cadmium Concentration. Journal of Toxicology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-465380
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465380