Association of IS605 and cag-PAI of Helicobacter pylori Isolated from Patients with Gastrointestinal Diseases in Taiwan
Joint Authors
Lai, Chih-Ho
Lan, Keng-Hsin
Perng, Chin-Lin
Lin, Hwai-Jeng
Source
Gastroenterology Research and Practice
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-17
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
The cag pathogenicity island (cag-PAI) is one of the most important virulent determinants of Helicobacter pylori.
An insertion sequence (IS) element of cag-PAI (IS605) has been found to generate H.
pylori strains with varying virulence.
Aim.
To evaluate the impact of IS605 and cag-PAI on H.
pylori strains isolated from Taiwanese patients with severity of gastric diseases.
Methods.
H.
pylori isolates were cultured from gastric biopsies from 99 patients with peptic ulcer, chronic gastritis, and gastric carcinoma.
Six distinct, well-separated colonies were isolated from each patient and analyzed by genotyping.
Results.
cagA, cagE, cagM, cagT, orf10, and orf13 were found to be present in 90.0%–100.0% of the H.
pylori isolates.
A total deletion of cagA, cagE, cagM, cagT, orf10, and orf13 was found in 1 isolate (1.0%).
The IS605 element was found to be positive in 15.2% of the isolates.
The presence of IS605 was higher in H.
pylori isolated from patients with gastric carcinoma (25.0%) than in patients with duodenal ulcer (6.5%) or chronic gastritis (6.3%) (P<0.001).
Conclusions.
The majority of the patients examined had intact cag-PAI.
IS605 was present in 15.2% and was higher in H.
pylori isolated from patients with gastric carcinoma than in those with peptic ulcer.
American Psychological Association (APA)
Lai, Chih-Ho& Perng, Chin-Lin& Lan, Keng-Hsin& Lin, Hwai-Jeng. 2013. Association of IS605 and cag-PAI of Helicobacter pylori Isolated from Patients with Gastrointestinal Diseases in Taiwan. Gastroenterology Research and Practice،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-465394
Modern Language Association (MLA)
Lai, Chih-Ho…[et al.]. Association of IS605 and cag-PAI of Helicobacter pylori Isolated from Patients with Gastrointestinal Diseases in Taiwan. Gastroenterology Research and Practice No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-465394
American Medical Association (AMA)
Lai, Chih-Ho& Perng, Chin-Lin& Lan, Keng-Hsin& Lin, Hwai-Jeng. Association of IS605 and cag-PAI of Helicobacter pylori Isolated from Patients with Gastrointestinal Diseases in Taiwan. Gastroenterology Research and Practice. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-465394
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465394