Decrease of Total Antioxidative Capacity in Developed Low Cardiac Output Syndrome
Joint Authors
Andac, Mehmet Halit
Kunt, Alper Sami
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-28
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Background.
It has been known that cardiac surgery induces an oxidative stress.
The persistent oxidative stress during reperfusion may lead to depressed myocardial function resulting in low cardiac output syndrome (LCOS) necessitating inotropic or intra-aortic balloon counterpulsation support.
Total antioxidant capacity (TAC) is a measurement of oxidative stress in tissues.
The purpose of this study was to examine the TAC differences during coronary artery bypass graft (CABG) operation in patients who have developed LCOS and who have not.
Material and Methods.
Seventy-nine patients were enrolled in the study.
Central venous blood samples were obtained immediately before surgery, during operation, and at the end of surgery to assess TAC.
Clinical data regarding patient demographics and operative outcomes were prospectively collected and entered into our clinical database.
Results.
LCOS developed in 8 patients (10.12%).
The TAC has decreased sharply in the LCOS patients compared with those who did not develop LCOS (P<0.001) during operation.
In addition, the receiver operating characteristic (ROC) area was 0.879.
Conclusion.
TAC has decreased during operation in a significant proportion of patients undergoing isolated CABG, and this is more prominent and serious and might be an independent variable in patients who have developed LCOS.
This may be related to intraoperative misadventure or inadequate myocardial antioxidative protection.
Routine measurement of the TAC during operation may provide information for assessment of the LCOS development.
American Psychological Association (APA)
Kunt, Alper Sami& Andac, Mehmet Halit. 2012. Decrease of Total Antioxidative Capacity in Developed Low Cardiac Output Syndrome. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-465408
Modern Language Association (MLA)
Kunt, Alper Sami& Andac, Mehmet Halit. Decrease of Total Antioxidative Capacity in Developed Low Cardiac Output Syndrome. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-465408
American Medical Association (AMA)
Kunt, Alper Sami& Andac, Mehmet Halit. Decrease of Total Antioxidative Capacity in Developed Low Cardiac Output Syndrome. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-465408
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465408