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Potential for Cell-Transplant Therapy with Human Neuronal Precursors to Treat Neuropathic Pain in Models of PNS and CNS Injury : Comparison of hNT2.17 and hNT2.19 Cell Lines
Joint Authors
Eaton, Mary J.
Berrocal, Yerko
Wolfe, Stacey Quintero
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-31, 31 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-24
Country of Publication
Egypt
No. of Pages
31
Main Subjects
Abstract EN
Effective treatment of sensory neuropathies in peripheral neuropathies and spinal cord injury (SCI) is one of the most difficult problems in modern clinical practice.
Cell therapy to release antinociceptive agents near the injured spinal cord is a logical next step in the development of treatment modalities.
But few clinical trials, especially for chronic pain, have tested the potential of transplant of cells to treat chronic pain.
Cell lines derived from the human neuronal NT2 cell line parentage, the hNT2.17 and hNT2.19 lines, which synthesize and release the neurotransmitters gamma-aminobutyric acid (GABA) and serotonin (5HT), respectively, have been used to evaluate the potential of cell-based release of antinociceptive agents near the lumbar dorsal (horn) spinal sensory cell centers to relieve neuropathic pain after PNS (partial nerve and diabetes-related injury) and CNS (spinal cord injury) damage in rat models.
Both cell lines transplants potently and permanently reverse behavioral hypersensitivity without inducing tumors or other complications after grafting.
Functioning as cellular minipumps for antinociception, human neuronal precursors, like these NT2-derived cell lines, would likely provide a useful adjuvant or replacement for current pharmacological treatments for neuropathic pain.
American Psychological Association (APA)
Eaton, Mary J.& Berrocal, Yerko& Wolfe, Stacey Quintero. 2012. Potential for Cell-Transplant Therapy with Human Neuronal Precursors to Treat Neuropathic Pain in Models of PNS and CNS Injury : Comparison of hNT2.17 and hNT2.19 Cell Lines. Pain Research and Treatment،Vol. 2012, no. 2012, pp.1-31.
https://search.emarefa.net/detail/BIM-465416
Modern Language Association (MLA)
Eaton, Mary J.…[et al.]. Potential for Cell-Transplant Therapy with Human Neuronal Precursors to Treat Neuropathic Pain in Models of PNS and CNS Injury : Comparison of hNT2.17 and hNT2.19 Cell Lines. Pain Research and Treatment No. 2012 (2012), pp.1-31.
https://search.emarefa.net/detail/BIM-465416
American Medical Association (AMA)
Eaton, Mary J.& Berrocal, Yerko& Wolfe, Stacey Quintero. Potential for Cell-Transplant Therapy with Human Neuronal Precursors to Treat Neuropathic Pain in Models of PNS and CNS Injury : Comparison of hNT2.17 and hNT2.19 Cell Lines. Pain Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-31.
https://search.emarefa.net/detail/BIM-465416
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465416