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FDG-PET Quantification of Lung Inflammation with Image-Derived Blood Input Function in Mice
Joint Authors
Zhong, Min
Williams, Mark B.
Kundu, Bijoy K.
Locke, Landon W.
Berr, Stuart S.
Fairchild, Karen D.
Source
International Journal of Molecular Imaging
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-10
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Dynamic FDG-PET imaging was used to study inflammation in lungs of mice following administration of a virulent strain of Klebsiella (K.) pneumoniae.
Net whole-lung FDG influx constant (Ki) was determined in a compartment model using an image-derived blood input function.
Methods.
K.
pneumoniae (~3 x 105 CFU) was intratracheally administered to six mice with 6 other mice serving as controls.
Dynamic FDG-PET and X-Ray CT scans were acquired 24 hr after K.
pneumoniae administration.
The experimental lung time activity curves were fitted to a 3-compartment FDG model to obtain Ki.
Following imaging, lungs were excised and immunohistochemistry analysis was done to assess the relative presence of neutrophils and macrophages.
Results.
Mean Ki for control and K.
pneumoniae infected mice were (5.1±1.2) ×10-3 versus (11.4±2.0) ×10-3 min−1, respectively, revealing a 2.24 fold significant increase (P=0.0003) in the rate of FDG uptake in the infected lung.
Immunohistochemistry revealed that cellular lung infiltrate was almost exclusively neutrophils.
Parametric Ki maps by Patlak analysis revealed heterogeneous inflammatory foci within infected lungs.
Conclusion.
The kinetics of FDG uptake in the lungs of mice can be noninvasively quantified by PET with a 3-compartment model approach based on an image-derived input function.
American Psychological Association (APA)
Locke, Landon W.& Williams, Mark B.& Fairchild, Karen D.& Zhong, Min& Kundu, Bijoy K.& Berr, Stuart S.. 2011. FDG-PET Quantification of Lung Inflammation with Image-Derived Blood Input Function in Mice. International Journal of Molecular Imaging،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-465440
Modern Language Association (MLA)
Locke, Landon W.…[et al.]. FDG-PET Quantification of Lung Inflammation with Image-Derived Blood Input Function in Mice. International Journal of Molecular Imaging No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-465440
American Medical Association (AMA)
Locke, Landon W.& Williams, Mark B.& Fairchild, Karen D.& Zhong, Min& Kundu, Bijoy K.& Berr, Stuart S.. FDG-PET Quantification of Lung Inflammation with Image-Derived Blood Input Function in Mice. International Journal of Molecular Imaging. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-465440
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465440