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Mouse WRN Helicase Domain Is Not Required for Spontaneous Homologous Recombination-Mediated DNA Deletion
Joint Authors
Claybon, Alison B.
Brown, Adam D.
Bishop, Alexander J. R.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-08-19
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Werner syndrome is a rare disorder that manifests as premature aging and age-related diseases.
WRN is the gene mutated in WS, and is one of five human RecQ helicase family members.
WS cells exhibit genomic instability and altered proliferation, and in vitro studies suggest that WRN has a role in suppressing homologous recombination.
However, more recent studies propose that other RecQ helicases (including WRN) promote early events of homologous recombination.
To study the role of WRN helicase on spontaneous homologous recombination, we obtained a mouse with a deleted WRN helicase domain and combined it with the in vivo pink-eyed unstable homologous recombination system.
In this paper, we demonstrate that WRN helicase is not necessary for suppressing homologous recombination in vivo contrary to previous reports using a similar mouse model.
American Psychological Association (APA)
Brown, Adam D.& Claybon, Alison B.& Bishop, Alexander J. R.. 2010. Mouse WRN Helicase Domain Is Not Required for Spontaneous Homologous Recombination-Mediated DNA Deletion. Journal of Nucleic Acids،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-465463
Modern Language Association (MLA)
Brown, Adam D.…[et al.]. Mouse WRN Helicase Domain Is Not Required for Spontaneous Homologous Recombination-Mediated DNA Deletion. Journal of Nucleic Acids No. 2010 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-465463
American Medical Association (AMA)
Brown, Adam D.& Claybon, Alison B.& Bishop, Alexander J. R.. Mouse WRN Helicase Domain Is Not Required for Spontaneous Homologous Recombination-Mediated DNA Deletion. Journal of Nucleic Acids. 2010. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-465463
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465463