Premedication with Oral Alprazolam and Melatonin Combination : A Comparison with Either Alone—A Randomized Controlled Factorial Trial
Joint Authors
Khatiwada, Sindhu
Subedi, Asish
Bhattarai, Balkrishna
Gupta, Pramod Kumar
Pokharel, Krishna
Tripathi, Mukesh
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
We assessed if the addition of melatonin to alprazolam has superior premedication effects compared to either drug alone.
A prospective, double blind placebo controlled trial randomly assigned 80 adult patients (ASA 1&2) with a Visual Analogue Score (VAS) for anxiety ≥3 to receive a tablet containing a combination of alprazolam 0.5 mg and melatonin 3 mg, alprazolam 0.5 mg, melatonin 3 mg, or placebo orally 90 min before a standard anesthetic.
Primary end points were change in anxiety and sedation score at 15, 30, and 60 min after premedication, and number of patients with loss of memory for the five pictures shown at various time points when assessed after 24 h.
One-way ANOVA, Friedman repeated measures analysis of variance, Kruskal Wallis and chi square tests were used as relevant.
Combination drug produced the maximum reduction in anxiety VAS (3 (1.0–4.3)) from baseline at 60 min (P<0.05).
Sedation scores at various time points and number of patients not recognizing the picture shown at 60 min after premedication were comparable between combination drug and alprazolam alone.
Addition of melatonin to alprazolam had superior anxiolysis compared with either drugs alone or placebo.
Adding melatonin neither worsened sedation score nor the amnesic effect of alprazolam alone.
This study was registered, approved, and released from ClinicalTrials.gov.
Identifier number: NCT01486615.
American Psychological Association (APA)
Pokharel, Krishna& Tripathi, Mukesh& Gupta, Pramod Kumar& Bhattarai, Balkrishna& Khatiwada, Sindhu& Subedi, Asish. 2014. Premedication with Oral Alprazolam and Melatonin Combination : A Comparison with Either Alone—A Randomized Controlled Factorial Trial. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-465470
Modern Language Association (MLA)
Pokharel, Krishna…[et al.]. Premedication with Oral Alprazolam and Melatonin Combination : A Comparison with Either Alone—A Randomized Controlled Factorial Trial. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-465470
American Medical Association (AMA)
Pokharel, Krishna& Tripathi, Mukesh& Gupta, Pramod Kumar& Bhattarai, Balkrishna& Khatiwada, Sindhu& Subedi, Asish. Premedication with Oral Alprazolam and Melatonin Combination : A Comparison with Either Alone—A Randomized Controlled Factorial Trial. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-465470
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465470