Imatinib : A Breakthrough of Targeted Therapy in Cancer
Joint Authors
Source
Chemotherapy Research and Practice
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Deregulated protein tyrosine kinase activity is central to the pathogenesis of human cancers.
Targeted therapy in the form of selective tyrosine kinase inhibitors (TKIs) has transformed the approach to management of various cancers and represents a therapeutic breakthrough.
Imatinib was one of the first cancer therapies to show the potential for such targeted action.
Imatinib, an oral targeted therapy, inhibits tyrosine kinases specifically BCR-ABL, c-KIT, and PDGFRA.
Apart from its remarkable success in CML and GIST, Imatinib benefits various other tumors caused by Imatinib-specific abnormalities of PDGFR and c-KIT.
Imatinib has also been proven to be effective in steroid-refractory chronic graft-versus-host disease because of its anti-PDGFR action.
This paper is a comprehensive review of the role of Imatinib in oncology.
American Psychological Association (APA)
Iqbal, Nida& Iqbal, Naveed. 2014. Imatinib : A Breakthrough of Targeted Therapy in Cancer. Chemotherapy Research and Practice،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-465478
Modern Language Association (MLA)
Iqbal, Nida& Iqbal, Naveed. Imatinib : A Breakthrough of Targeted Therapy in Cancer. Chemotherapy Research and Practice No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-465478
American Medical Association (AMA)
Iqbal, Nida& Iqbal, Naveed. Imatinib : A Breakthrough of Targeted Therapy in Cancer. Chemotherapy Research and Practice. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-465478
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465478