Anti-Integrin Therapy for Multiple Sclerosis
Joint Authors
Okamoto, Takayuki
Imai, Hiroshi
Nakahashi, Susumu
Shimaoka, Motomu
Kawamoto, Eiji
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-17
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Integrins are the foremost family of cell adhesion molecules that regulate immune cell trafficking in health and diseases.
Integrin alpha4 mediates organ-specific migration of immune cells to the inflamed brain, thereby playing the critical role in the pathogenesis of multiple sclerosis.
Anti-alpha4 integrin therapy aiming to block infiltration of autoreactive lymphocytes to the inflamed brain has been validated in several clinical trials for the treatment of multiple sclerosis.
This paper provides readers with an overview of the molecular and structural bases of integrin activation as well as rationale for using anti-alpha4 integrin therapy for multiple sclerosis and then chronicles the rise and fall of this treatment strategy using natalizumab, a humanized anti-alpha4 integrin.
American Psychological Association (APA)
Kawamoto, Eiji& Nakahashi, Susumu& Okamoto, Takayuki& Imai, Hiroshi& Shimaoka, Motomu. 2012. Anti-Integrin Therapy for Multiple Sclerosis. Autoimmune Diseases،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-465490
Modern Language Association (MLA)
Kawamoto, Eiji…[et al.]. Anti-Integrin Therapy for Multiple Sclerosis. Autoimmune Diseases No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-465490
American Medical Association (AMA)
Kawamoto, Eiji& Nakahashi, Susumu& Okamoto, Takayuki& Imai, Hiroshi& Shimaoka, Motomu. Anti-Integrin Therapy for Multiple Sclerosis. Autoimmune Diseases. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-465490
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465490