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Biologic and Genetics Aspects of Chagas Disease at Endemic Areas
Joint Authors
Bellini, Marilanda Ferreira
Silistino-Souza, Rosana
de Azeredo-Oliveira, Maria Tercília Vilela
Silva, Ana Elizabete
Varella-Garcia, Marileila
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-08
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The etiologic agent of Chagas Disease is the Trypanosoma cruzi, transmitted through blood-sucking insect vectors of the Triatominae subfamily, representing one of the most serious public health concerns in Latin America.
There are geographic variations in the prevalence of clinical forms and morbidity of Chagas disease, likely due to genetic variation of the T.
cruzi and the host genetic and environmental features.
Increasing evidence has supported that inflammatory cytokines and chemokines are responsible for the generation of the inflammatory infiltrate and tissue damage.
Moreover, genetic polymorphisms, protein expression levels, and genomic imbalances are associated with disease progression.
This paper discusses these key aspects.
Large surveys were carried out in Brazil and served as baseline for definition of the control measures adopted.
However, Chagas disease is still active, and aspects such as host-parasite interactions, genetic mechanisms of cellular interaction, genetic variability, and tropism need further investigations in the attempt to eradicate the disease.
American Psychological Association (APA)
Bellini, Marilanda Ferreira& Silistino-Souza, Rosana& Varella-Garcia, Marileila& de Azeredo-Oliveira, Maria Tercília Vilela& Silva, Ana Elizabete. 2012. Biologic and Genetics Aspects of Chagas Disease at Endemic Areas. Journal of Tropical Medicine،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-465563
Modern Language Association (MLA)
Bellini, Marilanda Ferreira…[et al.]. Biologic and Genetics Aspects of Chagas Disease at Endemic Areas. Journal of Tropical Medicine No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-465563
American Medical Association (AMA)
Bellini, Marilanda Ferreira& Silistino-Souza, Rosana& Varella-Garcia, Marileila& de Azeredo-Oliveira, Maria Tercília Vilela& Silva, Ana Elizabete. Biologic and Genetics Aspects of Chagas Disease at Endemic Areas. Journal of Tropical Medicine. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-465563
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465563