Corticostriatal Plastic Changes in Experimental L-DOPA-Induced Dyskinesia
Joint Authors
Picconi, Barbara
Calabresi, Paolo
Ghiglieri, Veronica
Pendolino, Valentina
Bagetta, Vincenza
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
In Parkinson’s disease (PD), alteration of dopamine- (DA-) dependent striatal functions and pulsatile stimulation of DA receptors caused by the discontinuous administration of levodopa (L-DOPA) lead to a complex cascade of events affecting the postsynaptic striatal neurons that might account for the appearance of L-DOPA-induced dyskinesia (LID).
Experimental models of LID have been widely used and extensively characterized in rodents and electrophysiological studies provided remarkable insights into the inner mechanisms underlying L-DOPA-induced corticostriatal plastic changes.
Here we provide an overview of recent findings that represent a further step into the comprehension of mechanisms underlying maladaptive changes of basal ganglia functions in response to L-DOPA and associated to development of LID.
American Psychological Association (APA)
Ghiglieri, Veronica& Bagetta, Vincenza& Pendolino, Valentina& Picconi, Barbara& Calabresi, Paolo. 2012. Corticostriatal Plastic Changes in Experimental L-DOPA-Induced Dyskinesia. Advances in Chemistry،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-465590
Modern Language Association (MLA)
Ghiglieri, Veronica…[et al.]. Corticostriatal Plastic Changes in Experimental L-DOPA-Induced Dyskinesia. Advances in Chemistry No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-465590
American Medical Association (AMA)
Ghiglieri, Veronica& Bagetta, Vincenza& Pendolino, Valentina& Picconi, Barbara& Calabresi, Paolo. Corticostriatal Plastic Changes in Experimental L-DOPA-Induced Dyskinesia. Advances in Chemistry. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-465590
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465590