Modular Crelox System and Genetic Therapeutics for Colorectal Cancer
Author
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-09-30
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The Cre/lox system is a powerful tool for targeting therapeutic effectors in a wide variety of human disorders.
I review a Cre/lox Wnt-targeted system that has shown promise against Wnt-positive colorectal cancer cell lines.
In addition to Wnt-specific targeting of cell death inducers, the modular nature of this gene therapy model system can be exploited by designing positive and negative feedback loops to either amplify or inhibit Wnt activity for experimental or therapeutic benefit.
I discuss the structural components and performance parameters of the system, the implication of these findings with respect to cancer stem cells, as well as the general applicability of this system to any disorder characterized by differential gene expression.
I also consider the issue of gene delivery as well as in vivo testing requirements necessary for the further characterization and development of this system.
American Psychological Association (APA)
Bordonaro, Michael. 2009. Modular Crelox System and Genetic Therapeutics for Colorectal Cancer. Journal of Biomedicine and Biotechnology،Vol. 2009, no. 2009, pp.1-12.
https://search.emarefa.net/detail/BIM-465599
Modern Language Association (MLA)
Bordonaro, Michael. Modular Crelox System and Genetic Therapeutics for Colorectal Cancer. Journal of Biomedicine and Biotechnology No. 2009 (2009), pp.1-12.
https://search.emarefa.net/detail/BIM-465599
American Medical Association (AMA)
Bordonaro, Michael. Modular Crelox System and Genetic Therapeutics for Colorectal Cancer. Journal of Biomedicine and Biotechnology. 2009. Vol. 2009, no. 2009, pp.1-12.
https://search.emarefa.net/detail/BIM-465599
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465599