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Iron Loading and Overloading due to Ineffective Erythropoiesis
Joint Authors
Miller, Jeffery Lynn
Tanno, Toshihiko
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-05-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Erythropoiesis describes the hematopoietic process of cell proliferation and differentiation that results in the production of mature circulating erythrocytes.
Adult humans produce 200 billion erythrocytes daily, and approximately 1 billion iron molecules are incorporated into the hemoglobin contained within each erythrocyte.
Thus, iron usage for the hemoglobin production is a primary regulator of plasma iron supply and demand.
In many anemias, additional sources of iron from diet and tissue stores are needed to meet the erythroid demand.
Among a subset of anemias that arise from ineffective erythropoiesis, iron absorption and accumulation in the tissues increases to levels that are in excess of erythropoiesis demand even in the absence of transfusion.
The mechanisms responsible for iron overloading due to ineffective erythropoiesis are not fully understood.
Based upon data that is currently available, it is proposed in this review that loading and overloading of iron can be regulated by distinct or combined mechanisms associated with erythropoiesis.
The concept of erythroid regulation of iron is broadened to include both physiological and pathological hepcidin suppression in cases of ineffective erythropoiesis.
American Psychological Association (APA)
Tanno, Toshihiko& Miller, Jeffery Lynn. 2010. Iron Loading and Overloading due to Ineffective Erythropoiesis. Advances in Hematology،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-465606
Modern Language Association (MLA)
Tanno, Toshihiko& Miller, Jeffery Lynn. Iron Loading and Overloading due to Ineffective Erythropoiesis. Advances in Hematology No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-465606
American Medical Association (AMA)
Tanno, Toshihiko& Miller, Jeffery Lynn. Iron Loading and Overloading due to Ineffective Erythropoiesis. Advances in Hematology. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-465606
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465606