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Nucleic Acid-Based Therapy Approaches for Huntington's Disease
Joint Authors
Young, Deborah
Mouravlev, Alexandre
Vagner, Tatyana
Source
Neurology Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Huntington's disease (HD) is caused by a dominant mutation that results in an unstable expansion of a CAG repeat in the huntingtin gene leading to a toxic gain of function in huntingtin protein which causes massive neurodegeneration mainly in the striatum and clinical symptoms associated with the disease.
Since the mutation has multiple effects in the cell and the precise mechanism of the disease remains to be elucidated, gene therapy approaches have been developed that intervene in different aspects of the condition.
These approaches include increasing expression of growth factors, decreasing levels of mutant huntingtin, and restoring cell metabolism and transcriptional balance.
The aim of this paper is to outline the nucleic acid-based therapeutic strategies that have been tested to date.
American Psychological Association (APA)
Vagner, Tatyana& Young, Deborah& Mouravlev, Alexandre. 2012. Nucleic Acid-Based Therapy Approaches for Huntington's Disease. Neurology Research International،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-465615
Modern Language Association (MLA)
Vagner, Tatyana…[et al.]. Nucleic Acid-Based Therapy Approaches for Huntington's Disease. Neurology Research International No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-465615
American Medical Association (AMA)
Vagner, Tatyana& Young, Deborah& Mouravlev, Alexandre. Nucleic Acid-Based Therapy Approaches for Huntington's Disease. Neurology Research International. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-465615
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465615