The Role of Phosphoinositide 3-Kinase Signaling in Intestinal Inflammation
Joint Authors
Walker, W. Allan
Cahill, Catherine M.
Rogers, Jack T.
Source
Journal of Signal Transduction
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-09
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The phosphatidylinositol 3-kinase signaling pathway plays a central role in regulating the host inflammatory response.
The net effect can either be pro- or anti-inflammatory depending on the system and cellular context studied.
This paper focuses on phosphatidylinositol 3-kinase signaling in innate and adaptive immune cells of the intestinal mucosa.
The role of phosphatidylinositol 3-kinase signaling in mouse models of inflammatory bowel disease is also discussed.
With the development of new isoform specific inhibitors, we are beginning to understand the specific role of this complex pathway, in particular the role of the γ isoform in intestinal inflammation.
Continued research on this complex pathway will enhance our understanding of its role and provide rationale for the design of new approaches to intervention in chronic inflammatory conditions such as inflammatory bowel disease.
American Psychological Association (APA)
Cahill, Catherine M.& Rogers, Jack T.& Walker, W. Allan. 2012. The Role of Phosphoinositide 3-Kinase Signaling in Intestinal Inflammation. Journal of Signal Transduction،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-465627
Modern Language Association (MLA)
Cahill, Catherine M.…[et al.]. The Role of Phosphoinositide 3-Kinase Signaling in Intestinal Inflammation. Journal of Signal Transduction No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-465627
American Medical Association (AMA)
Cahill, Catherine M.& Rogers, Jack T.& Walker, W. Allan. The Role of Phosphoinositide 3-Kinase Signaling in Intestinal Inflammation. Journal of Signal Transduction. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-465627
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465627