Molecular Analysis of TTF-1 and TTF-2 Genes in Patients with Early Onset Papillary Thyroid Carcinoma
Joint Authors
Bugalho, Maria João M.
Espadinha, Carla
Silva, Ana Luísa
Cabrera, Rafael
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-11
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Two common variants, close from TTF-1 and TTF-2, were shown to predispose to thyroid cancer (TC) in European populations.
We aimed to investigate whether TTF-1 and TTF-2 variants might contribute to TC early onset (EO).
Tumor samples from eighteen patients with papillary TC (PTC), who underwent total thyroidectomy at an age of ≤21, were screened for TTF-1 and TTF-2 variants.
No TTF-1 variants were documented; two novel germinal TTF-2 variants, c.200C>G (p.A67G) and c.510C>A (p.A170A), were identified in two patients.
Two already described TTF-2 variants were also documented; the allelic frequency among patients was not different from that observed among controls.
Moreover, RET/PTC rearrangements and the BRAFV600E mutation were identified in 5/18 and 2/18 PTCs, respectively.
Thyroglobulin (TG) and thyroid peroxidase (TPO) expression was found to be significantly decreased in tumors, and the lowest level of TPO expression occurred in a tumor harboring both the p.A67GTTF-2 variant and a RET/PTC3 rearrangement.
American Psychological Association (APA)
Espadinha, Carla& Silva, Ana Luísa& Cabrera, Rafael& Bugalho, Maria João M.. 2012. Molecular Analysis of TTF-1 and TTF-2 Genes in Patients with Early Onset Papillary Thyroid Carcinoma. Journal of Oncology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-465699
Modern Language Association (MLA)
Espadinha, Carla…[et al.]. Molecular Analysis of TTF-1 and TTF-2 Genes in Patients with Early Onset Papillary Thyroid Carcinoma. Journal of Oncology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-465699
American Medical Association (AMA)
Espadinha, Carla& Silva, Ana Luísa& Cabrera, Rafael& Bugalho, Maria João M.. Molecular Analysis of TTF-1 and TTF-2 Genes in Patients with Early Onset Papillary Thyroid Carcinoma. Journal of Oncology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-465699
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465699