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Peroxisome Proliferator-Activated Receptors as Mediators of Phthalate-Induced Effects in the Male and Female Reproductive Tract : Epidemiological and Experimental Evidence
Joint Authors
Latini, Giuseppe
De Felice, Claudio
Scoditti, Egeria
Verrotti, Alberto
Massaro, Marika
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2007-12-06
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
There is growing evidence that male as well as female reproductive function has been declining in human and wildlife populations over the last 40 years.
Several factors such as lifestyle or environmental xenobiotics other than genetic factors may play a role in determining adverse effects on reproductive health.
Among the environmental xenobiotics phthalates, a family of man-made pollutants are suspected to interfere with the function of the endocrine system and therefore to be endocrine disruptors.
The definition of endocrine disruption is today extended to broader endocrine regulations, and includes activation of metabolic sensors, such as the peroxisome proliferator-activated receptors (PPARs).
Toxicological studies have shown that phthalates can activate a subset of PPARs.
Here, we analyze the epidemiological and experimental evidence linking phthalate exposure to both PPAR activation and adverse effects on male and female reproductive health.
American Psychological Association (APA)
Latini, Giuseppe& Scoditti, Egeria& Verrotti, Alberto& De Felice, Claudio& Massaro, Marika. 2007. Peroxisome Proliferator-Activated Receptors as Mediators of Phthalate-Induced Effects in the Male and Female Reproductive Tract : Epidemiological and Experimental Evidence. PPAR Research،Vol. 2008, no. 2008, pp.1-13.
https://search.emarefa.net/detail/BIM-465701
Modern Language Association (MLA)
Latini, Giuseppe…[et al.]. Peroxisome Proliferator-Activated Receptors as Mediators of Phthalate-Induced Effects in the Male and Female Reproductive Tract : Epidemiological and Experimental Evidence. PPAR Research No. 2008 (2008), pp.1-13.
https://search.emarefa.net/detail/BIM-465701
American Medical Association (AMA)
Latini, Giuseppe& Scoditti, Egeria& Verrotti, Alberto& De Felice, Claudio& Massaro, Marika. Peroxisome Proliferator-Activated Receptors as Mediators of Phthalate-Induced Effects in the Male and Female Reproductive Tract : Epidemiological and Experimental Evidence. PPAR Research. 2007. Vol. 2008, no. 2008, pp.1-13.
https://search.emarefa.net/detail/BIM-465701
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465701