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Physiologically Based Toxicokinetic Modelling as a Tool to Support Risk Assessment : Three Case Studies
Joint Authors
Gundert-Remy, Ursula
Mielke, Hans
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-09
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Pharmacy, Health & Medical Sciences
Medicine
Abstract EN
In this contribution we present three case studies of physiologically based toxicokinetic (PBTK) modelling in regulatory risk assessment.
(1) Age-dependent lower enzyme expression in the newborn leads to bisphenol A (BPA) blood levels which are near the levels of the tolerated daily intake (TDI) at the oral exposure as calculated by EFSA.
(2) Dermal exposure of BPA by receipts, car park tickets, and so forth, contribute to the exposure towards BPA.
However, at the present levels of dermal exposure there is no risk for the adult.
(3) Dermal exposure towards coumarin via cosmetic products leads to external exposures of two-fold the TDI.
PBTK modeling helped to identify liver peak concentration as the metric for liver toxicity.
After dermal exposure of twice the TDI, the liver peak concentration was lower than that present after oral exposure with the TDI dose.
In the presented cases, PBTK modeling was useful to reach scientifically sound regulatory decisions.
American Psychological Association (APA)
Mielke, Hans& Gundert-Remy, Ursula. 2012. Physiologically Based Toxicokinetic Modelling as a Tool to Support Risk Assessment : Three Case Studies. Journal of Toxicology،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-465723
Modern Language Association (MLA)
Mielke, Hans& Gundert-Remy, Ursula. Physiologically Based Toxicokinetic Modelling as a Tool to Support Risk Assessment : Three Case Studies. Journal of Toxicology No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-465723
American Medical Association (AMA)
Mielke, Hans& Gundert-Remy, Ursula. Physiologically Based Toxicokinetic Modelling as a Tool to Support Risk Assessment : Three Case Studies. Journal of Toxicology. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-465723
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465723