Maturation of Corpus Callosum Anterior Midbody Is Associated with Neonatal Motor Function in Eight Preterm-Born Infants
Joint Authors
Finnigan, Simon
Guzzetta, Andrea
Mathew, Preethi
Rose, Stephen E.
Colditz, Paul B.
Snow, Pamela
D'Acunto, M. Giulia
Pannek, Kerstin
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
The etiology of motor impairments in preterm infants is multifactorial and incompletely understood.
Whether corpus callosum development is related to impaired motor function is unclear.
Potential associations between motor-related measures and diffusion tensor imaging (DTI) of the corpus callosum in preterm infants were explored.
Methods.
Eight very preterm infants (gestational age of 28–32 weeks) underwent the Hammersmith neonatal neurological examination and DTI assessments at gestational age of 42 weeks.
The total Hammersmith score and a motor-specific score (sum of Hammersmith motor subcategories) were calculated.
Six corpus callosum regions of interest were defined on the mid-sagittal DTI slice—genu, rostral body, anterior midbody, posterior midbody, isthmus, and splenium.
The fractional anisotropy (FA) and mean diffusivity (MD) of these regions were computed, and correlations between these and Hammersmith measures were sought.
Results.
Anterior midbody FA measures correlated positively with total Hammersmith (rho =0.929, P=0.001) and motor-specific scores (rho =0.857, P=0.007).
Total Hammersmith scores also negatively correlated with anterior midbody MD measures (rho =−0.714, P=0.047).
Discussion.
These results suggest the integrity of corpus callosum axons, particularly anterior midbody axons, is important in mediating neurological functions.
Greater callosal maturation was associated with greater motor function.
Corpus callosum DTI may prove to be a valuable screening or prognostic marker.
American Psychological Association (APA)
Mathew, Preethi& Pannek, Kerstin& Snow, Pamela& D'Acunto, M. Giulia& Guzzetta, Andrea& Rose, Stephen E.…[et al.]. 2013. Maturation of Corpus Callosum Anterior Midbody Is Associated with Neonatal Motor Function in Eight Preterm-Born Infants. Neural Plasticity،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-465733
Modern Language Association (MLA)
Mathew, Preethi…[et al.]. Maturation of Corpus Callosum Anterior Midbody Is Associated with Neonatal Motor Function in Eight Preterm-Born Infants. Neural Plasticity No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-465733
American Medical Association (AMA)
Mathew, Preethi& Pannek, Kerstin& Snow, Pamela& D'Acunto, M. Giulia& Guzzetta, Andrea& Rose, Stephen E.…[et al.]. Maturation of Corpus Callosum Anterior Midbody Is Associated with Neonatal Motor Function in Eight Preterm-Born Infants. Neural Plasticity. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-465733
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465733