Measurement of Salivary Resistin Level in Patients with Type 2 Diabetes
Joint Authors
Xu, Lu
Gao, Hongfei
Yin, Jinhua
Li, Ming
Yang, Jing
Source
International Journal of Endocrinology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-30
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Serum resistin was initially hypothesized as a link between obesity and insulin resistance in mice.
The latest evidence suggests that serum resistin is proinflammatory cytokines.
Inflammation plays a key role in the pathogenesis of type 2 diabetes mellitus (T2DM).
Many reports have previously identified changed serum resistin levels in patients with T2DM, but little is known of the levels of resistin in saliva.
In our study, saliva and serum samples were collected from 38 patients with newly diagnosed T2DM at each time point of OGTT and 35 nondiabetic controls at fasting state.
Resistin concentrations were measured using ELISA.
We have demonstrated the presence of resistin in saliva of T2DM and nondiabetic subjects.
Saliva resistin levels of T2DM are significantly higher than those of nondiabetic controls.
Resistin levels in saliva are not affected by eating activity and correlated with serum resistin levels at any time points of OGTT.
A positive correlation of serum and salivary resistin with BMI and HOMA-IR existed in T2DM.
Measurement of resistin in saliva is a simple, noninvasive and may be an acceptable alternative to blood sampling for evaluatinginflammation/obesity/insulin resistance state.
American Psychological Association (APA)
Yin, Jinhua& Gao, Hongfei& Yang, Jing& Xu, Lu& Li, Ming. 2012. Measurement of Salivary Resistin Level in Patients with Type 2 Diabetes. International Journal of Endocrinology،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-465749
Modern Language Association (MLA)
Yin, Jinhua…[et al.]. Measurement of Salivary Resistin Level in Patients with Type 2 Diabetes. International Journal of Endocrinology No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-465749
American Medical Association (AMA)
Yin, Jinhua& Gao, Hongfei& Yang, Jing& Xu, Lu& Li, Ming. Measurement of Salivary Resistin Level in Patients with Type 2 Diabetes. International Journal of Endocrinology. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-465749
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465749