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Role of Heme Oxygenase in Inflammation, Insulin-Signalling, Diabetes and Obesity
Author
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-05-18
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Diabetes and obesity are chronic conditions associated with elevated oxidative/inflammatory activities with a continuum of tissue insults leading to more severe cardiometabolic and renal complications including myocardial infarction and end-stage-renal damage.
A common denominator of these chronic conditions is the enhanced the levels of cytokines like tumour necrosis factor-alpha (TNF-α), interleukin (IL-6), IL-1β and resistin, which in turn activates the c-Jun-N-terminal kinase (JNK) and NF-κB pathways, creating a vicious cycle that exacerbates insulin resistance, type-2 diabetes and related complications.
Emerging evidence indicates that heme oxygenase (HO) inducers are endowed with potent anti-diabetic and insulin sensitizing effects besides their ability to suppress immune/inflammatory response.
Importantly, the HO system abates inflammation through several mechanisms including the suppression of macrophage-infiltration and abrogation of oxidative/inflammatory transcription factors like NF-κB, JNK and activating protein-1.
This review highlights the mechanisms by which the HO system potentiates insulin signalling, with particular emphasis on HO-mediated suppression of oxidative and inflammatory insults.
The HO system could be explored in the search for novel remedies against cardiometabolic diseases and their complications.
American Psychological Association (APA)
Ndisang, Joseph Fomusi. 2010. Role of Heme Oxygenase in Inflammation, Insulin-Signalling, Diabetes and Obesity. Mediators of Inflammation،Vol. 2010, no. 2010, pp.1-18.
https://search.emarefa.net/detail/BIM-465750
Modern Language Association (MLA)
Ndisang, Joseph Fomusi. Role of Heme Oxygenase in Inflammation, Insulin-Signalling, Diabetes and Obesity. Mediators of Inflammation No. 2010 (2010), pp.1-18.
https://search.emarefa.net/detail/BIM-465750
American Medical Association (AMA)
Ndisang, Joseph Fomusi. Role of Heme Oxygenase in Inflammation, Insulin-Signalling, Diabetes and Obesity. Mediators of Inflammation. 2010. Vol. 2010, no. 2010, pp.1-18.
https://search.emarefa.net/detail/BIM-465750
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465750