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Tamarind Seed Xyloglucans Promote Proliferation and Migration of Human Skin Cells through Internalization via Stimulation of Proproliferative Signal Transduction Pathways
Joint Authors
Source
Dermatology Research and Practice
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-09
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Xyloglucans (XGs) of Tamarindus indica L.
Fabaceae are used as drug vehicles or as ingredients of cosmetics.
Two xyloglucans were extracted from T.
indica seed with cold water (TSw) and copper complex precipitation (TSc).
Both were analyzed in regard to composition and influence on cell viability, proliferation, cell cycle progression, migration, MAPK phosphorylation, and gene expression of human skin keratinocytes (NHEK and HaCaT) and fibroblasts (NHDF) in vitro.
TSw and TSc differed in molecular weight, rhamnose content, and ratios of xylose, arabinose, galactose, and glucose.
Both XGs improved keratinocytes and fibroblast proliferation, promoted the cell cycle, and stimulated migration and intracellular enzyme activity of NHDF after endosomal uptake.
Only TSw significantly enhanced HaCaT migration and extracellular enzyme activity of NHDF and HaCaT.
TSw and TSc predominantly enhanced the phosphorylation of molecules that referred to Erk signaling in NHEK.
In NHDF parts of the integrin signaling and SAPK/JNK pathway were affected.
Independent of cell type TSw marginally regulated the expression of genes, which referred to membrane proteins, cytoskeleton, cytokine signaling, and ECM as well as to processes of metabolism and transcription.
Results show that T.
indica xyloglucans promote skin regeneration by a direct influence on cell proliferation and migration.
American Psychological Association (APA)
Nie, W.& Deters, Alexandra M.. 2013. Tamarind Seed Xyloglucans Promote Proliferation and Migration of Human Skin Cells through Internalization via Stimulation of Proproliferative Signal Transduction Pathways. Dermatology Research and Practice،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-465755
Modern Language Association (MLA)
Nie, W.& Deters, Alexandra M.. Tamarind Seed Xyloglucans Promote Proliferation and Migration of Human Skin Cells through Internalization via Stimulation of Proproliferative Signal Transduction Pathways. Dermatology Research and Practice No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-465755
American Medical Association (AMA)
Nie, W.& Deters, Alexandra M.. Tamarind Seed Xyloglucans Promote Proliferation and Migration of Human Skin Cells through Internalization via Stimulation of Proproliferative Signal Transduction Pathways. Dermatology Research and Practice. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-465755
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465755