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Human Herpesviridae Methods of Natural Killer Cell Evasion
Joint Authors
Cassady, Kevin A.
Markert, James M.
Odom, Carl I.
Gaston, David C.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-08
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Human herpesviruses cause diseases of considerable morbidity and mortality, ranging from encephalitis to hematologic malignancies.
As evidence emerges about the role of innate immunity and natural killer (NK) cells in the control of herpesvirus infection, evidence of viral methods of innate immune evasion grows as well.
These methods include interference with the ligands on infected cell surfaces that bind NK cell activating or inhibitory receptors.
This paper summarizes the most extensively studied NK cell receptor/ligand pairs and then describes the methods of NK cell evasion used by all eight herpesviruses through these receptors and ligands.
Although great strides have been made in elucidating their mechanisms, there is still a disparity between viruses in the amount of knowledge regarding innate immune evasion.
Further research of herpesvirus innate immune evasion can provide insight for circumventing viral mechanisms in future therapies.
American Psychological Association (APA)
Odom, Carl I.& Gaston, David C.& Markert, James M.& Cassady, Kevin A.. 2012. Human Herpesviridae Methods of Natural Killer Cell Evasion. Advances in Virology،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-465765
Modern Language Association (MLA)
Odom, Carl I.…[et al.]. Human Herpesviridae Methods of Natural Killer Cell Evasion. Advances in Virology No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-465765
American Medical Association (AMA)
Odom, Carl I.& Gaston, David C.& Markert, James M.& Cassady, Kevin A.. Human Herpesviridae Methods of Natural Killer Cell Evasion. Advances in Virology. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-465765
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465765