ITIH4 : A New Potential Biomarker of “Toxin Syndrome” in Coronary Heart Disease Patient Identified with Proteomic Method
Joint Authors
Shi, Da-Zhuo
Xu, Hao
Li, Geng
Shang, Qing-hua
Du, Jianpeng
Chen, Ke-Ji
Chen, Hao
Wen, Jianyan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-19
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Objective.
This trial aims to look for the protein biomarker of “toxin syndrome” of CHD patients.
Methods.
We have performed two trials in this paper.
The first trial was a randomized controlled trial (RCT) of the plasma proteome in unstable angina (UA) patients by Maldi-Tof Mass.
The second trial was a nested case-control study in 1503 stable CHD patients with one-year followup for acute cardiovascular events (ACEs).
Results.
In the RCT study, 12 protein spots were found to be the differential protein for the significant differences between the difference of before and after treatment in group A and group B; 2 of them (3207.37 Da and 4279.95 Da) was considered to be unique to “toxin syndrome” for being differential proteins of group B but not group A.
These 2 spots were identified as Isoform 1 of Fibrinogen alpha chain precursor (FGA, 3207.37 Da) and Isoform 2 of inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4, 4279.95 Da), respectively.
In the nested case-control study, the result of Western blot demonstrated that protein expression of ITIH4 in the group with followup ACEs was significantly lower than the matched group without followup ACEs (P=0.027).
Conclusion.
ITIH4 might be a new potential biomarker of CHD “toxin syndrome” in TCM, indicating the potential role in early identifying high-risk CHD patients in stable period.
American Psychological Association (APA)
Xu, Hao& Shang, Qing-hua& Chen, Hao& Du, Jianpeng& Wen, Jianyan& Li, Geng…[et al.]. 2013. ITIH4 : A New Potential Biomarker of “Toxin Syndrome” in Coronary Heart Disease Patient Identified with Proteomic Method. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-465774
Modern Language Association (MLA)
Xu, Hao…[et al.]. ITIH4 : A New Potential Biomarker of “Toxin Syndrome” in Coronary Heart Disease Patient Identified with Proteomic Method. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-465774
American Medical Association (AMA)
Xu, Hao& Shang, Qing-hua& Chen, Hao& Du, Jianpeng& Wen, Jianyan& Li, Geng…[et al.]. ITIH4 : A New Potential Biomarker of “Toxin Syndrome” in Coronary Heart Disease Patient Identified with Proteomic Method. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-465774
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465774