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Safety and Efficacy of Stereotactic Body Radiation Therapy in the Treatment of Pulmonary Metastases from High Grade Sarcoma
Joint Authors
Agazaryan, Nzhde
Chmielowski, Bartosz
Lee, Percy
Steinberg, Michael
Wang, Pin-Chieh
Eilber, Fritz C.
Mehta, Niraj
Federman, Noah
Selch, Michael
Lee, Jay M.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-01
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Introduction.
Patients with high-grade sarcoma (HGS) frequently develop metastatic disease thus limiting their long-term survival.
Lung metastases (LM) have historically been treated with surgical resection (metastasectomy).
A potential alternative for controlling LM could be stereotactic body radiation therapy (SBRT).
We evaluated the outcomes from our institutional experience utilizing SBRT.
Methods.
Sixteen consecutive patients with LM from HGS were treated with SBRT between 2009 and 2011.
Routine radiographic and clinical follow-up was performed.
Local failure was defined as CT progression on 2 consecutive scans or growth after initial shrinkage.
Radiation pneumonitis and radiation esophagitis were scored using Common Toxicity Criteria (CTC) version 3.0.
Results.
All 16 patients received chemotherapy, and a subset (38%) also underwent prior pulmonary metastasectomy.
Median patient age was 56 (12–85), and median follow-up time was 20 months (range 3–43).
A total of 25 lesions were treated and evaluable for this analysis.
Most common histologies were leiomyosarcoma (28%), synovial sarcoma (20%), and osteosarcoma (16%).
Median SBRT prescription dose was 54 Gy (36–54) in 3-4 fractions.
At 43 months, local control was 94%.
No patient experienced G2-4 radiation pneumonitis, and no patient experienced radiation esophagitis.
Conclusions.
Our retrospective experience suggests that SBRT for LM from HGS provides excellent local control and minimal toxicity.
American Psychological Association (APA)
Mehta, Niraj& Selch, Michael& Wang, Pin-Chieh& Federman, Noah& Lee, Jay M.& Eilber, Fritz C.…[et al.]. 2013. Safety and Efficacy of Stereotactic Body Radiation Therapy in the Treatment of Pulmonary Metastases from High Grade Sarcoma. Sarcoma،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-465782
Modern Language Association (MLA)
Mehta, Niraj…[et al.]. Safety and Efficacy of Stereotactic Body Radiation Therapy in the Treatment of Pulmonary Metastases from High Grade Sarcoma. Sarcoma No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-465782
American Medical Association (AMA)
Mehta, Niraj& Selch, Michael& Wang, Pin-Chieh& Federman, Noah& Lee, Jay M.& Eilber, Fritz C.…[et al.]. Safety and Efficacy of Stereotactic Body Radiation Therapy in the Treatment of Pulmonary Metastases from High Grade Sarcoma. Sarcoma. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-465782
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465782