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Therapeutic Applications of Carbon Monoxide
Joint Authors
Vangala, Sandeep
Knauert, Melissa
Haslip, Maria
Lee, Patty J.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-04
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Heme oxygenase-1 (HO-1) is a regulated enzyme induced in multiple stress states.
Carbon monoxide (CO) is a product of HO catalysis of heme.
In many circumstances, CO appears to functionally replace HO-1, and CO is known to have endogenous anti-inflammatory, anti-apoptotic, and antiproliferative effects.
CO is well studied in anoxia-reoxygenation and ischemia-reperfusion models and has advanced to phase II trials for treatment of several clinical entities.
In alternative injury models, laboratories have used sepsis, acute lung injury, and systemic inflammatory challenges to assess the ability of CO to rescue cells, organs, and organisms.
Hopefully, the research supporting the protective effects of CO in animal models will translate into therapeutic benefits for patients.
Preclinical studies of CO are now moving towards more complex damage models that reflect polymicrobial sepsis or two-step injuries, such as sepsis complicated by acute respiratory distress syndrome.
Furthermore, co-treatment and post-treatment with CO are being explored in which the insult occurs before there is an opportunity to intervene therapeutically.
The aim of this review is to discuss the potential therapeutic implications of CO with a focus on lung injury and sepsis-related models.
American Psychological Association (APA)
Knauert, Melissa& Vangala, Sandeep& Haslip, Maria& Lee, Patty J.. 2013. Therapeutic Applications of Carbon Monoxide. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-465837
Modern Language Association (MLA)
Knauert, Melissa…[et al.]. Therapeutic Applications of Carbon Monoxide. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-465837
American Medical Association (AMA)
Knauert, Melissa& Vangala, Sandeep& Haslip, Maria& Lee, Patty J.. Therapeutic Applications of Carbon Monoxide. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-465837
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465837