Performance of Clinical Algorithms for Smear-Negative Tuberculosis in HIV-Infected Persons in Ho Chi Minh City, Vietnam
Joint Authors
Nguyen, Duc T. M.
Hwang, Lu-Yu
Ford, Charles E.
Nguyen, Hung Q.
Graviss, Edward A.
Beasley, R. Palmer
Source
Tuberculosis Research and Treatment
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-25
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Tuberculosis (TB) disease diagnosis in Vietnam relies on symptom screening, chest radiography (CXR), and acid fast bacilli (AFB) sputum smear which have a poor sensitivity in HIV patients.
We evaluated the performance of clinical algorithms in screening and diagnosing AFB smear-negative TB in HIV patients.
Methods.
We enrolled 399 HIV-positive patients seeking care at a HIV clinic in Ho Chi Minh City (HCMC), Vietnam.
Participants’ demographics, medical history, common TB symptoms, CXR, and laboratory tests were collected.
Results.
Of 399 HIV patients, 390 had initial AFB-negative smears and 22/390 patients had positive cultures.
Symptom screening missed 54% (12/22) of smear-negative pulmonary TB (PTB) cases.
Multivariate analysis found CD4+ cell level and CXR were significant PTB predictors.
An algorithm combining four TB symptoms and TST presented a high sensitivity (100%), but poorly specific (24%) diagnostic performance for smear-negative PTB.
Conclusion.
Up to 54% of PTB cases in the HIV-infected population may be missed in the routine screening and diagnostic procedures used in Vietnam.
Symptom screening was a poor overall diagnostic measure in detecting smear-negative TB in HIV patients.
Our study results suggest that routine sputum cultures should be implemented to achieve a more accurate diagnosis of TB in HIV patients.
American Psychological Association (APA)
Nguyen, Duc T. M.& Nguyen, Hung Q.& Beasley, R. Palmer& Ford, Charles E.& Hwang, Lu-Yu& Graviss, Edward A.. 2012. Performance of Clinical Algorithms for Smear-Negative Tuberculosis in HIV-Infected Persons in Ho Chi Minh City, Vietnam. Tuberculosis Research and Treatment،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-465838
Modern Language Association (MLA)
Nguyen, Duc T. M.…[et al.]. Performance of Clinical Algorithms for Smear-Negative Tuberculosis in HIV-Infected Persons in Ho Chi Minh City, Vietnam. Tuberculosis Research and Treatment No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-465838
American Medical Association (AMA)
Nguyen, Duc T. M.& Nguyen, Hung Q.& Beasley, R. Palmer& Ford, Charles E.& Hwang, Lu-Yu& Graviss, Edward A.. Performance of Clinical Algorithms for Smear-Negative Tuberculosis in HIV-Infected Persons in Ho Chi Minh City, Vietnam. Tuberculosis Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-465838
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465838