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CDKCCN and CDKI Alterations for Cancer Prognosis and Therapeutic Predictivity
Joint Authors
Schiattarella, Antonietta
Tuccillo, Franca Maria
Bonelli, Patrizia
Buonaguro, Franco Maria
Borrelli, Antonella
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-29
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
The regulation of cell growth and division occurs in an accurate sequential manner.
It is dictated by the accumulation of cyclins (CCNs) and cyclin-dependent kinases (CDKs) complexes and degradation of CCNs.
In human tumors, instead, the cell cycle is deregulated, causing absence of differentiation and aberrant cell growth.
Oncogenic alterations of CCNs, CDKs, and CDKIs have been reported in more than 90% of human cancers, and the most frequent are those related to the G1 phase.
Several molecular mechanisms, including gene overexpression, chromosomal translocations, point mutations, insertions and deletions, missense and frame shift mutation, splicing, or methylation, may be responsible for these alterations.
The cell cycle regulators are involved in tumor progression given their association with cancers characterized by higher incidence of relapses and chemotherapy resistance.
In the last decade anticancer drug researches focused on new compounds, able to target molecules related to changes in genes associated with tumor status.
Recently, the studies have focused on the restoration of cell cycle control modulating molecular targets involved in cancer-cell alterations.
This paper aims to correlate alterations of cell cycle regulators with human cancers and therapeutic responsivity.
American Psychological Association (APA)
Bonelli, Patrizia& Tuccillo, Franca Maria& Borrelli, Antonella& Schiattarella, Antonietta& Buonaguro, Franco Maria. 2014. CDKCCN and CDKI Alterations for Cancer Prognosis and Therapeutic Predictivity. BioMed Research International،Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-465853
Modern Language Association (MLA)
Bonelli, Patrizia…[et al.]. CDKCCN and CDKI Alterations for Cancer Prognosis and Therapeutic Predictivity. BioMed Research International No. 2014 (2014), pp.1-15.
https://search.emarefa.net/detail/BIM-465853
American Medical Association (AMA)
Bonelli, Patrizia& Tuccillo, Franca Maria& Borrelli, Antonella& Schiattarella, Antonietta& Buonaguro, Franco Maria. CDKCCN and CDKI Alterations for Cancer Prognosis and Therapeutic Predictivity. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-465853
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465853