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Electroacupuncture Treatment Normalized Sleep Disturbance in Morphine Withdrawal Rats
Joint Authors
Wu, Liu-Zhen
Zhong, Fei
Cui, Cai-Lian
Li, Yi-Jing
Yu, Peng
Han, Ji-Sheng
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Sleep disturbance is considered as an important symptom of acute and protracted opiate withdrawal.
Current results suggest that sleep disturbance may be taken as a predictor of relapse.
Appropriate sleep enhancement therapy will be in favor of the retention in treatment for opiate addicts.
Our previous studies have shown that electroacupuncture (EA) is effective in suppressing morphine withdrawal syndrome.
The aim of the present study is to investigate the effect of 2 and 100 Hz EA on the sleep disturbance during morphine withdrawal.
Rats were made dependent on morphine by repeated morphine injections (escalating doses of 5–80 mg kg−1, subcutaneously, twice a day) for 5 days.
EA of 2 or 100 Hz was given twice a day for 3 days, starting at 48 h after the last morphine injection.
Electroencephalogram and electromyogram were monitored at the end of the first and the last EA treatments, respectively.
Results showed that non-rapid eye movement (NREM) sleep, REM sleep and total sleep time decreased dramatically, while the sleep latency prolonged significantly during acute morphine withdrawal.
Both 2 and 100 Hz EA produced a significant increase in NREM sleep, REM sleep and total sleep time.
It was suggested that EA could be a potential treatment for sleep disturbance during morphine withdrawal.
American Psychological Association (APA)
Li, Yi-Jing& Zhong, Fei& Yu, Peng& Han, Ji-Sheng& Cui, Cai-Lian& Wu, Liu-Zhen. 2011. Electroacupuncture Treatment Normalized Sleep Disturbance in Morphine Withdrawal Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-465855
Modern Language Association (MLA)
Li, Yi-Jing…[et al.]. Electroacupuncture Treatment Normalized Sleep Disturbance in Morphine Withdrawal Rats. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-465855
American Medical Association (AMA)
Li, Yi-Jing& Zhong, Fei& Yu, Peng& Han, Ji-Sheng& Cui, Cai-Lian& Wu, Liu-Zhen. Electroacupuncture Treatment Normalized Sleep Disturbance in Morphine Withdrawal Rats. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-465855
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465855