PD-L1 Blockade Attenuated Sepsis-Induced Liver Injury in a Mouse Cecal Ligation and Puncture Model
Joint Authors
Bo, Lulong
Zhu, Weimin
Tao, Tianzhu
Deng, Xiaoming
Zhu, Jiali
Wang, Jiafeng
Li, Jinbao
Fan, Xiaohua
Bao, Rui
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Liver plays a major role in hypermetabolism and produces acute phase proteins during systemic inflammatory response syndrome and it is of vital importance in host defense and bacteria clearance.
Our previous studies indicated that programmed death-1 (PD-1) and its ligand programmed death ligand-1 (PD-L1) are crucial modulators of host immune responses during sepsis.
Our current study was designed to investigate the role of PD-L1 in sepsis-induced liver injury by a mouse cecal ligation and puncture (CLP) model.
Our results indicated that there was a significant increase of PD-L1 expression in liver after CLP challenge compared to sham-operated controls, in terms of levels of mRNA transcription and immunohistochemistry.
Anti-PD-L1 antibody significantly alleviated the morphology of liver injury in CLP mice.
Anti-PD-L1 antibody administration decreased ALT and AST release in CLP mice, decreased the levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-10 mRNA in liver after sepsis challenge.
Thus, anti-PD-L1 antibody might have a therapeutic potential in attenuating liver injury in sepsis.
American Psychological Association (APA)
Zhu, Weimin& Bao, Rui& Fan, Xiaohua& Tao, Tianzhu& Zhu, Jiali& Wang, Jiafeng…[et al.]. 2013. PD-L1 Blockade Attenuated Sepsis-Induced Liver Injury in a Mouse Cecal Ligation and Puncture Model. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-465899
Modern Language Association (MLA)
Zhu, Weimin…[et al.]. PD-L1 Blockade Attenuated Sepsis-Induced Liver Injury in a Mouse Cecal Ligation and Puncture Model. Mediators of Inflammation No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-465899
American Medical Association (AMA)
Zhu, Weimin& Bao, Rui& Fan, Xiaohua& Tao, Tianzhu& Zhu, Jiali& Wang, Jiafeng…[et al.]. PD-L1 Blockade Attenuated Sepsis-Induced Liver Injury in a Mouse Cecal Ligation and Puncture Model. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-465899
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465899