Long-Term Outcome of Patients Followed by Nephrologists after an Acute Tubular Necrosis Episode

Abstract EN

Aims of our study were to describe the long-term survival in patients surviving an acute tubular necrosis (ATN) episode and determine factors associated with late mortality.

We performed a prospective cohort study that evaluated the long-term outcome of 212 patients surviving an ATN episode.

Mortality at the end of followup was 24.5%, and the probability of these patients being alive 5 years after discharge was 55%.

During the followup, 4.7% of patients needed chronic dialysis.

Univariate analysis showed that previous CKD (P=0.0079), cardiovascular disease (P=0.019), age greater than 60 years (P<0.0001), and higher SCr baseline (P=0.001), after 12 months (P=0.0015) and 36 months (P=0.004), were predictors of long-term mortality.

In multivariate analysis, older age (HR = 6.4, CI 95% = 1.2–34.5, P=0.02) and higher SCr after 12 months (HR = 2.1, 95% CI 95% = 1.14–4.1, P=0.017) were identified as risk factors associated with late mortality.

In conclusion, 55% of patients surviving an ATN episode were still alive, and less than 5% required chronic dialysis 60 months later; older age and increased Scr after 12 months were identified as risk factors associated with late death.