X-Ray Computed Tomography : Semiautomated Volumetric Analysis of Late-Stage Lung Tumors as a Basis for Response Assessments
Joint Authors
Schmidt, G.
Kietzmann, M.
Mozley, P. D.
Bendtsen, C.
Binnig, G.
Korn, R.
Source
International Journal of Biomedical Imaging
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-24
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
This study presents a semiautomated approach for volumetric analysis of lung tumors and evaluates the feasibility of using volumes as an alternative to line lengths as a basis for response evaluation criteria in solid tumors (RECIST).
The overall goal for the implementation was to accurately, precisely, and efficiently enable the analyses of lesions in the lung under the guidance of an operator.
Methods.
An anthropomorphic phantom with embedded model masses and 71 time points in 10 clinical cases with advanced lung cancer was analyzed using a semi-automated workflow.
The implementation was done using the Cognition Network Technology.
Results.
Analysis of the phantom showed an average accuracy of 97%.
The analyses of the clinical cases showed both intra- and interreader variabilities of approximately 5% on average with an upper 95% confidence interval of 14% and 19%, respectively.
Compared to line lengths, the use of volumes clearly shows enhanced sensitivity with respect to determining response to therapy.
Conclusions.
It is feasible to perform volumetric analysis efficiently with high accuracy and low variability, even in patients with late-stage cancer who have complex lesions.
American Psychological Association (APA)
Bendtsen, C.& Kietzmann, M.& Korn, R.& Mozley, P. D.& Schmidt, G.& Binnig, G.. 2011. X-Ray Computed Tomography : Semiautomated Volumetric Analysis of Late-Stage Lung Tumors as a Basis for Response Assessments. International Journal of Biomedical Imaging،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-465909
Modern Language Association (MLA)
Bendtsen, C.…[et al.]. X-Ray Computed Tomography : Semiautomated Volumetric Analysis of Late-Stage Lung Tumors as a Basis for Response Assessments. International Journal of Biomedical Imaging No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-465909
American Medical Association (AMA)
Bendtsen, C.& Kietzmann, M.& Korn, R.& Mozley, P. D.& Schmidt, G.& Binnig, G.. X-Ray Computed Tomography : Semiautomated Volumetric Analysis of Late-Stage Lung Tumors as a Basis for Response Assessments. International Journal of Biomedical Imaging. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-465909
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465909