Receptor Tyrosine Kinases : Molecular Switches Regulating CNS Axon Regeneration
Joint Authors
Kundi, Sarina
Vigneswara, Vasanthy
Ahmed, Zubair
Source
Journal of Signal Transduction
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-16
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The poor or lack of injured adult central nervous system (CNS) axon regeneration results in devastating consequences and poor functional recovery.
The interplay between the intrinsic and extrinsic factors contributes to robust inhibition of axon regeneration of injured CNS neurons.
The insufficient or lack of trophic support for injured neurons is considered as one of the major obstacles contributing to their failure to survive and regrow their axons after injury.
In the CNS, many of the signalling pathways associated with neuronal survival and axon regeneration are regulated by several classes of receptor tyrosine kinases (RTK) that respond to a variety of ligands.
This paper highlights and summarises the most relevant recent findings pertinent to different classes of the RTK family of molecules, with a particular focus on elucidating their role in CNS axon regeneration.
American Psychological Association (APA)
Vigneswara, Vasanthy& Kundi, Sarina& Ahmed, Zubair. 2012. Receptor Tyrosine Kinases : Molecular Switches Regulating CNS Axon Regeneration. Journal of Signal Transduction،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-465921
Modern Language Association (MLA)
Vigneswara, Vasanthy…[et al.]. Receptor Tyrosine Kinases : Molecular Switches Regulating CNS Axon Regeneration. Journal of Signal Transduction No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-465921
American Medical Association (AMA)
Vigneswara, Vasanthy& Kundi, Sarina& Ahmed, Zubair. Receptor Tyrosine Kinases : Molecular Switches Regulating CNS Axon Regeneration. Journal of Signal Transduction. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-465921
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465921