Insulin versus Lipid Emulsion in a Rabbit Model of Severe Propranolol Toxicity : A Pilot Study
Joint Authors
Hopgood, Gary
Harvey, Martyn
Cave, Grant
Desmet, Jan
Lahner, Daniel
Prince, Gaynor
Source
Critical Care Research and Practice
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background and objective.
Beta-blocker overdose may result in intractable cardiovascular collapse despite conventional antidotal treatments.
High dose insulin/glucose (ING), and more recently intravenous lipid emulsion (ILE), have been proposed as potentially beneficial therapies in beta blocker intoxication.
We compare efficacy of the novel antidotes ING, with ILE, in a rabbit model of combined enteric/intravenous propranolol toxicity.
Methods.
Sedated, mechanically ventilated and invasively monitored New Zealand White rabbits underwent mini-laparotomy and enterostomy formation with 40 mg/kg propranolol instilled into the proximal small bowel.
At 30 minutes propranolol infusion was commenced at 4 mg/kg/hr and continued to a target mean arterial pressure (MAP) of 50% baseline MAP.
Animals were resuscitated with insulin at 3 U/kg plus 0.5 g/kg glucose (ING group), or 10 mL/kg 20% Intralipid (ILE group).
Results.
Rate pressure product (RPP; RPP = heart rate × mean arterial pressure) was greatest in the ING group at 60 minutes (P<.05).
A trend toward greater heart rate was observed in the ING group (P=.06).
No difference was observed in survival between groups (4/5 ING versus 2/5 ILE; P=.524).
Conclusions.
High dose insulin resulted in greater rate pressure product compared with lipid emulsion in this rabbit model of severe enteric/intravenous propranolol toxicity.
American Psychological Association (APA)
Harvey, Martyn& Cave, Grant& Lahner, Daniel& Desmet, Jan& Prince, Gaynor& Hopgood, Gary. 2011. Insulin versus Lipid Emulsion in a Rabbit Model of Severe Propranolol Toxicity : A Pilot Study. Critical Care Research and Practice،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-465923
Modern Language Association (MLA)
Harvey, Martyn…[et al.]. Insulin versus Lipid Emulsion in a Rabbit Model of Severe Propranolol Toxicity : A Pilot Study. Critical Care Research and Practice No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-465923
American Medical Association (AMA)
Harvey, Martyn& Cave, Grant& Lahner, Daniel& Desmet, Jan& Prince, Gaynor& Hopgood, Gary. Insulin versus Lipid Emulsion in a Rabbit Model of Severe Propranolol Toxicity : A Pilot Study. Critical Care Research and Practice. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-465923
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465923