Effects of Roux-en-Y Gastric Bypass on Fasting and Postprandial Levels of the Inflammatory Markers YKL-40 and MCP-1 in Patients with Type 2 Diabetes and Glucose Tolerant Subjects
Joint Authors
Vestergaard, Henrik
Rathcke, Camilla Noelle
Thomsen, Stine Brinkløv
Jørgensen, Nils Bruun
Madsbad, Sten
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-03
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
The inflammatory markers YKL-40 and monocyte chemoattractant protein-1 (MCP-1) are elevated in morbidly obese patients and decline after weight loss.
The objective of our study was to investigate the possible changes of YKL-40 and MCP-1, in both the fasting and the postprandial states, following Roux-en-Y gastric bypass (RYGB) in subjects with type 2 diabetes (T2D) and normal glucose tolerance (NGT).
Methods.
Ten obese patients with T2D and 10 subjects with NGT were examined in the fasting state and after a standard meal prior to and after (1 week, 3 months, and 1 year) RYGB.
Results.
Fasting state MCP-1 levels decreased after RYGB in both groups (P values < 0.0001) whereas fasting YKL-40 levels were unchanged (P values ≥ 0.120).
Postprandial MCP-1 levels showed a tendency towards a decrease on most study days; however, the changes were only significant at 1 week (P=0.001) and 1 yr (P<0.0001) in the T2D group and at 3 mo after RYGB in the NGT group (P=0.009).
YKL-40 levels showed a slight, postprandial suppression on all study days in the T2D group (all P values ≤ 0.021).
Conclusions.
Fasting MCP-1 levels, but not YKL-40 levels, decrease after RYGB in subjects with T2D and NGT.
Postprandial changes of inflammatory markers are discrete and inconsistent.
American Psychological Association (APA)
Thomsen, Stine Brinkløv& Rathcke, Camilla Noelle& Jørgensen, Nils Bruun& Madsbad, Sten& Vestergaard, Henrik. 2013. Effects of Roux-en-Y Gastric Bypass on Fasting and Postprandial Levels of the Inflammatory Markers YKL-40 and MCP-1 in Patients with Type 2 Diabetes and Glucose Tolerant Subjects. Journal of Obesity،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-465925
Modern Language Association (MLA)
Thomsen, Stine Brinkløv…[et al.]. Effects of Roux-en-Y Gastric Bypass on Fasting and Postprandial Levels of the Inflammatory Markers YKL-40 and MCP-1 in Patients with Type 2 Diabetes and Glucose Tolerant Subjects. Journal of Obesity No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-465925
American Medical Association (AMA)
Thomsen, Stine Brinkløv& Rathcke, Camilla Noelle& Jørgensen, Nils Bruun& Madsbad, Sten& Vestergaard, Henrik. Effects of Roux-en-Y Gastric Bypass on Fasting and Postprandial Levels of the Inflammatory Markers YKL-40 and MCP-1 in Patients with Type 2 Diabetes and Glucose Tolerant Subjects. Journal of Obesity. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-465925
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465925