Anti- and Protumorigenic Effects of PPARγ in Lung Cancer Progression : A Double-Edged Sword
Joint Authors
Nemenoff, Raphael
Weiser-Evans, Mary C. M.
Li, Howard
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-12
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Peroxisome proliferator-activated receptor-γ (PPARγ) is a member of the nuclear receptor superfamily of ligand-activated transcription factors that plays an important role in the control of gene expression linked to a variety of physiological processes, including cancer.
Ligands for PPARγ include naturally occurring fatty acids and the thiazolidinedione class of antidiabetic drugs.
Activation of PPARγ in a variety of cancer cells leads to inhibition of growth, decreased invasiveness, reduced production of proinflammatory cytokines, and promotion of a more differentiated phenotype.
However, systemic activation of PPARγ has been reported to be protumorigenic in some in vitro systems and in vivo models.
Here, we review the available data that implicate PPARγ in lung carcinogenesis and highlight the challenges of targeting PPARγ in lung cancer treatments.
American Psychological Association (APA)
Li, Howard& Weiser-Evans, Mary C. M.& Nemenoff, Raphael. 2012. Anti- and Protumorigenic Effects of PPARγ in Lung Cancer Progression : A Double-Edged Sword. PPAR Research،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-465963
Modern Language Association (MLA)
Li, Howard…[et al.]. Anti- and Protumorigenic Effects of PPARγ in Lung Cancer Progression : A Double-Edged Sword. PPAR Research No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-465963
American Medical Association (AMA)
Li, Howard& Weiser-Evans, Mary C. M.& Nemenoff, Raphael. Anti- and Protumorigenic Effects of PPARγ in Lung Cancer Progression : A Double-Edged Sword. PPAR Research. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-465963
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465963