The Characteristics of Vascular Growth in VX2 Tumor Measured by MRI and Micro-CT
Joint Authors
Wright, G. A.
Liu, J.
Qi, X.-L.
Burns, P. N.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Blood supply is crucial for rapid growth of a malignant tumor; medical imaging can play an important role in evaluating the vascular characterstics of tumors.
Magnetic resonance imaging (MRI) and micro-computed tomography (CT) are able to detect tumors and measure blood volumes of microcirculation in tissue.
In this study, we used MR imaging and micro-CT to assess the microcirculation in a VX2 tumor model in rabbits.
MRI characterization was performed using the intravascular contrast agent Clariscan (NC100150-Injection); micro-CT with Microfil was used to directly depict blood vessels with diameters as low as 17 um in tissue.
Relative blood volume fraction (rBVF) in the tumor rim and blood vessel density (rBVD) over the whole tumor was calculated using the two imaging methods.
Our study indicates that rBVF is negatively related to the volume of the tumor measured by ultrasound (R=0.90).
rBVF in the tissue of a VX2 tumor measured by MRI in vivo was qualitatively consistent with the rBVD demonstrated by micro-CT in vitro (R=0.97).
The good correlation between the two methods indicates that MRI studies are potentially valuable for assessing characteristics or tumor vascularity and for assessing response to therapy noninvasively.
American Psychological Association (APA)
Qi, X.-L.& Liu, J.& Burns, P. N.& Wright, G. A.. 2011. The Characteristics of Vascular Growth in VX2 Tumor Measured by MRI and Micro-CT. Journal of Oncology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-465964
Modern Language Association (MLA)
Qi, X.-L.…[et al.]. The Characteristics of Vascular Growth in VX2 Tumor Measured by MRI and Micro-CT. Journal of Oncology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-465964
American Medical Association (AMA)
Qi, X.-L.& Liu, J.& Burns, P. N.& Wright, G. A.. The Characteristics of Vascular Growth in VX2 Tumor Measured by MRI and Micro-CT. Journal of Oncology. 2011. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-465964
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465964