Evolution and Conservation of Predicted Inclusion Membrane Proteins in Chlamydiae
Joint Authors
Lutter, Erika I.
Hackstadt, Ted
Martens, Craig
Source
Comparative and Functional Genomics
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-21
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Chlamydia spp.
are obligate intracellular pathogens that replicate within a vacuole termed the inclusion.
Chlamydiae extensively modify the inclusion membrane via the insertion of chlamydial inclusion membrane proteins (Incs) which decorate the cytosolic face of the inclusion.
We have assessed the overall relatedness and phylogeny of Incs in order to identify potential evolutionary trends.
Despite a high degree of conservation among Incs within C.
trachomatis serovars, phylogenetic analysis showed that some Incs cluster according to clinical groupings suggesting that certain Incs may contribute to tissue tropism.
Bioinformatic predictions identified Incs in five chlamydial species: 55 in C.
trachomatis, 68 in C.
felis, 92 in C.
pneumoniae, 79 in C.
caviae, and 54 in C.
muridarum.
Inc homologues were compared between chlamydial species and 23 core Incs were identified as shared among all species.
Genomic expansion of Incs was identified in C.
pneumoniae, C.
caviae, and C.
felis but not C.
trachomatis or C.
muridarum.
American Psychological Association (APA)
Lutter, Erika I.& Martens, Craig& Hackstadt, Ted. 2012. Evolution and Conservation of Predicted Inclusion Membrane Proteins in Chlamydiae. Comparative and Functional Genomics،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-465965
Modern Language Association (MLA)
Lutter, Erika I.…[et al.]. Evolution and Conservation of Predicted Inclusion Membrane Proteins in Chlamydiae. Comparative and Functional Genomics No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-465965
American Medical Association (AMA)
Lutter, Erika I.& Martens, Craig& Hackstadt, Ted. Evolution and Conservation of Predicted Inclusion Membrane Proteins in Chlamydiae. Comparative and Functional Genomics. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-465965
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465965